Time to drink: Activating lateral hypothalamic area neurotensin neurons promotes intake of fluid over food in a time-dependent manner.

Autor: Kurt G; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Kodur N; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Quiles CR; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Reynolds C; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Eagle A; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Mayer T; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Brown J; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA., Makela A; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Bugescu R; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Seo HD; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Carroll QE; Department of Psychology and the Center for Ingestive Behavior Research, University at Buffalo, the State University of New York, Buffalo, NY 14226, USA., Daniels D; Department of Psychology and the Center for Ingestive Behavior Research, University at Buffalo, the State University of New York, Buffalo, NY 14226, USA., Robison AJ; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Mazei-Robison M; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Leinninger G; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: leinning@msu.edu.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2022 Apr 01; Vol. 247, pp. 113707. Date of Electronic Publication: 2022 Jan 19.
DOI: 10.1016/j.physbeh.2022.113707
Abstrakt: The lateral hypothalamic area (LHA) is essential for ingestive behavior but has primarily been studied in modulating feeding, with comparatively scant attention on drinking. This is partly because most LHA neurons simultaneously promote feeding and drinking, suggesting that ingestive behaviors track together. A notable exception are LHA neurons expressing neurotensin (LHA Nts neurons): activating these neurons promotes water intake but modestly restrains feeding. Here we investigated the connectivity of LHA Nts neurons, their necessity and sufficiency for drinking and feeding, and how timing and resource availability influence their modulation of these behaviors. LHA Nts neurons project broadly throughout the brain, including to the lateral preoptic area (LPO), a brain region implicated in modulating drinking behavior. LHA Nts neurons also receive inputs from brain regions implicated in sensing hydration and energy status. While activation of LHA Nts neurons is not required to maintain homeostatic water or food intake, it selectively promotes drinking during the light cycle, when ingestive drive is low. Activating LHA Nts neurons during this period also increases willingness to work for water or palatable fluids, regardless of their caloric content. By contrast, LHA Nts neuronal activation during the dark cycle does not promote drinking, but suppresses feeding during this time. Finally, we demonstrate that the activation of the LHA Nts  → LPO projection is sufficient to mediate drinking behavior, but does not suppress feeding as observed after generally activating all LHA Nts neurons. Overall, our work suggests how and when LHA Nts neurons oppositely modulate ingestive behaviors.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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