COVID-19 mortality is associated with low vitamin D levels in patients with risk factors and/or advanced age.
| Autor: | Jenei T; Department of Pulmonology, Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: drjeneitimea@gmail.com., Jenei S; Department of Informatics, Institute of Mathematics and Informatics, University of Pécs, 6. Ifjúság u., 7624 Pécs, Hungary. Electronic address: jenei@ttk.pte.hu., Tamás LT; Department of Otorhinolaryngology, Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: ltamas@gyor.net., Putics Á; Department of Microbiology Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: akos.putics@gmail.com., Knausz M; Department of Microbiology Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: drknauszmarta@gmail.com., Hegedüs I; Department of Infectology, Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: hegedus.iren.dr@gmail.com., Dinnyés I; Department of Laboratory, Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: dinnyesimre@gmail.com., Szalai Z; Department of Pulmonology, Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: drszalaizs@gmail.com., Molnár TF; Department of Operational Medicine, Faculty of Medicine, University of Pécs, 12. Szigeti u., 7624 Pécs, Hungary; St. Sebastian Thoracic Surgery Unit, Department of Surgery, Petz Aladár University Teaching Hospital, 2-4. Vasvári Pál u., 9023 Győr, Hungary. Electronic address: tfmolnar@gmail.com., Büki B; Department of Otorhinolaryngology, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, A-3500 Krems an der Donau, Austria. Electronic address: bela.bueki@krems.lknoe.at. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical nutrition ESPEN [Clin Nutr ESPEN] 2022 Feb; Vol. 47, pp. 410-413. Date of Electronic Publication: 2021 Nov 24. |
| DOI: | 10.1016/j.clnesp.2021.11.025 |
| Abstrakt: | Background & Aims: Although conclusive evidence is yet lacking, it has been suggested that vitamin D deficiency (VD) may be associated with a more severe course of SARS-CoV-2 Infection (COVID-19). In this retrospective study we assessed the association of VD deficiency with mortality in a group of COVID-19 patients treated in a tertiary referral center. Methods: Data of 257 Covid-19 patients hospitalized between 30th September 2020 and 2nd March 2021 have been collected retrospectively. The following parameters were collected: age, gender, serum level of 25-OH-Vitamin D Results: VD levels were significantly lower in patients who did not survive, however, in this patients' group the average age was significantly higher than among those, who survived. After age-matching, in a subgroup of patients with risk factors and/or 60 years of age or older who survived had significantly higher VD level in their serum than those who deceased. Serum C-reactive protein, lactate-dehydrogenase and creatinin-kinase were significantly higher in the group in which the patients died, however these laboratory parameters did not correlate with the VD levels. Conclusion: We found that in COVID-19 infection, when old age as risk factor (60 years of age or older) was pooled with risk factors (cancer, diabetes and/or COPD), the VD levels were significantly lower in the patient group, in which the patients did not survive. We suggest further, prospective studies in similar subgroups to explore a possible causal relationship. Competing Interests: Declaration of competing interest The authors do not declare any conflicts of interest. (Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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