Progress in drug-delivery systems in cardiovascular applications: stents, balloons and nanoencapsulation.

Autor:	Ng JCK; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore, 117583, Singapore., Toong DWY; Department of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore, 639798, Singapore., Ow V; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore, 117583, Singapore., Chaw SY; Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore., Toh H; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore, 117583, Singapore., Wong PEH; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore., Venkatraman S; Department of Material Science Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117575, Singapore., Chong TT; Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.; Department of Vascular Surgery, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore., Tan LP; Department of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore, 639798, Singapore., Huang YY; Department of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore, 639798, Singapore., Ang HY; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore, 117583, Singapore.; Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
Jazyk:	angličtina
Zdroj:	Nanomedicine (London, England) [Nanomedicine (Lond)] 2022 Feb; Vol. 17 (5), pp. 325-347. Date of Electronic Publication: 2022 Jan 21.
DOI:	10.2217/nnm-2021-0288
Abstrakt:	Drug-delivery systems in cardiovascular applications regularly include the use of drug-eluting stents and drug-coated balloons to ensure sufficient drug transfer and efficacy in the treatment of cardiovascular diseases. In addition to the delivery of antiproliferative drugs, the use of growth factors, genetic materials, hormones and signaling molecules has led to the development of different nanoencapsulation techniques for targeted drug delivery. The review will cover drug delivery and coating mechanisms in current drug-eluting stents and drug-coated balloons, novel innovations in drug-eluting stent technologies and drug encapsulation in nanocarriers for delivery in vascular diseases. Newer technologies and advances in nanoencapsulation techniques, such as the use of liposomes, nanogels and layer-by-layer coating to deliver therapeutics in the cardiovascular space, will be highlighted.
Databáze:	MEDLINE
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