Biomarkers involved in the proliferation of the odontogenic keratocyst, glandular odontogenic cyst and botryoid odontogenic cyst.

Autor: Júnior JF; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Natal-RN, Brazil., de França GM; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova Natal-RN, CEP, 59056-000, Brazil. gloriafracam@gmail.com., da Silva Barros CC; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Natal-RN, Brazil., Felix FA; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Natal-RN, Brazil., da Silva WR; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Natal-RN, Brazil., de Lucena HF; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Natal-RN, Brazil., Oliveira CN; Department of Pathology, Health Sciences, Federal University of Rio Grande Do Norte, Natal-RN, Brazil., Galvão HC; Dental Science Postgraduate Program, Federal University of Rio Grande Do Norte, Natal-RN, Brazil.
Jazyk: angličtina
Zdroj: Oral and maxillofacial surgery [Oral Maxillofac Surg] 2022 Dec; Vol. 26 (4), pp. 655-662. Date of Electronic Publication: 2022 Jan 21.
DOI: 10.1007/s10006-021-01026-x
Abstrakt: Introduction: Odontogenic cysts are a heterogeneous group of lesions with varied clinical behavior.
Objective: To analyze the expression of the epidermal growth factor receptor (EGFR), Cyclin D1, and transcription factor SOX2 in the odontogenic epithelium evaluating the cell cycle control and cystic expansion.
Methods: This was a cross-sectional study including 40 cases, 20 odontogenic keratocysts (OKC), 10 botryoid odontogenic cysts (BOC), and 10 glandular odontogenic cysts (GOC).
Results: All cases of OKC, BOC, and GOC were positive for EGFR in all layers of the cyst lining. The highest expression of nuclear Cyclin D1 was observed in the suprabasal layer of OKCs and in the basal and suprabasal layers of GOC and BOC (p < 0.001). In addition, SOX2 was only expressed in the suprabasal layer of OKCs.
Conclusion: The high expression of EGFR in the cyst membrane suggests that EGF stimulates epithelial proliferation in BOCs, and the high expression of SOX2 in OKCs may be related to the presence of stem cells in the lesion. Cyclin D1 is related to cell cycle disruption in G1-S contributing to stimulates epithelial proliferation of OKCs and GOCs and BOCs.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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