Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria.

Autor:	Nolan VC; College of Health and Life Sciences, Aston University, B4 7ET, Birmingham, United Kingdom., Rafols L; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom., Harrison J; College of Health and Life Sciences, Aston University, B4 7ET, Birmingham, United Kingdom., Soldevila-Barreda JJ; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom., Crosatti M; CL3 facility, Division of Biomedical Services, University of Leicester, LE1 7RH, Leicester, United Kingdom., Garton NJ; Department of Respiratory Sciences and Leicester TB Research Group, University of Leicester, LE1 7RH, Leicester, United Kingdom., Wegrzyn M; CL3 facility, Division of Biomedical Services, University of Leicester, LE1 7RH, Leicester, United Kingdom., Timms DL; College of Health and Life Sciences, Aston University, B4 7ET, Birmingham, United Kingdom., Seaton CC; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom., Sendron H; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom., Azmanova M; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom., Barry NPE; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom., Pitto-Barry A; School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom.; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France., Cox JAG; College of Health and Life Sciences, Aston University, B4 7ET, Birmingham, United Kingdom.
Jazyk:	angličtina
Zdroj:	Current research in microbial sciences [Curr Res Microb Sci] 2021 Dec 16; Vol. 3, pp. 100099. Date of Electronic Publication: 2021 Dec 16 (Print Publication: 2022).
DOI:	10.1016/j.crmicr.2021.100099
Abstrakt:	Antimicrobial resistant (AMR) bacteria are emerging and spreading globally, threatening our ability to treat common infectious diseases. The development of new classes of antibiotics able to kill or inhibit the growth of such AMR bacteria through novel mechanisms of action is therefore urgently needed. Here, a new family of indole-containing arene ruthenium organometallic compounds are screened against several bacterial species and drug resistant strains. The most active complex [( p -cym)Ru(O-cyclohexyl- 1H -indole-2-carbothioate)Cl] ( 3 ) shows growth inhibition and bactericidal activity against different organisms ( Acinetobacter baumannii, Mycobacterium abscessus, Mycobacterium tuberculosis, Staphylococcus aureus, Salmonella enterica serovar Typhi and Escherichia coli ), demonstrating broad-spectrum inhibitory activity. Importantly, this compound series exhibits low toxicity against human cells. Owing to the novelty of the antibiotic family, their moderate cytotoxicity, and their inhibitory activity against Gram positive, Gram negative and acid-fast, antibiotic resistant microorganisms, this series shows significant promise for further development. Competing Interests: Nicolas Barry, Anaïs Pitto-Barry, Joan Soldevila-Barreda, and Jonathan Cox have patent #International PCT Application No. PCT/GB2021/050471 pending to Aston University and University of Bradford. (© 2021 The Author(s). Published by Elsevier B.V.)
Databáze:	MEDLINE
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