Aqueous Humor Levels of Vascular Endothelial Growth Factor and Stromal Cell-Derived Factor-1α in Age-Related Macular Degeneration.
Autor: | Keles A; Department of Ophthalmology, Bilecik Seyh Edebali University Faculty of Medicine, Bilecik, Turkey., Erol YO; Department of Ophthalmology, University of Health Science, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Ayyildiz SN; Department of Medical Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey., Karaman SK; Department of Ophthalmology, University of Health Science, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Ogus E; Department of Medical Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey. |
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Jazyk: | angličtina |
Zdroj: | Beyoglu eye journal [Beyoglu Eye J] 2021 Dec 17; Vol. 6 (4), pp. 298-303. Date of Electronic Publication: 2021 Dec 17 (Print Publication: 2021). |
DOI: | 10.14744/bej.2021.49140 |
Abstrakt: | Objectives: This study investigated the contribution of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF-1α) angiogenic mediators in eyes with age-related macular degeneration (AMD). Methods: Aqueous humor specimens taken during cataract surgery in 7 cases of intermediate stage (nonexudative) AMD and 7 cases of late stage (exudative) AMD were evaluated using chemiluminescent immunoassay testing in this prospective case-control study. Mediator levels were compared with the normal reference values of 7 patients without any disease other than cataract. Results: The groups were similar in terms of age and gender (p>0.05). The aqueous humor levels of VEGF in both the intermediate AMD (median: 224.3 pg/mL, range: 44.8-380.4 pg/mL) and late-stage AMD (median: 108.7 pg/mL, range: 61.9-223.5 pg/mL) patients were similar to those of the control group (median: 121.1 pg/mL, range: 24.9-156.6 pg/mL) (p=0.256). Moreover, there was no significant difference in the SDF-1α concentrations between the intermediate AMD (median: 160.9 pg/mL, range 130-166.3 pg/mL), late AMD (median: 161 pg/mL, range: 154.1.9-171.6 pg/mL), and control group values (median: 161 pg/mL, range: 155.2-219 pg/mL) (p=0.763). Conclusion: The aqueous humor levels of VEGF and SDF-1α were within the normal range in patients with intermediate and late-stage AMD. (Copyright © 2021 by Beyoglu Eye Training and Research Hospital.) |
Databáze: | MEDLINE |
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