Syncytin, envelope protein of human endogenous retrovirus (HERV): no longer 'fossil' in human genome.

Autor: Durnaoglu S; College of Natural Sciences, Hanyang University, Seoul, Republic of Korea.; Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea., Lee SK; College of Natural Sciences, Hanyang University, Seoul, Republic of Korea.; Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea., Ahnn J; College of Natural Sciences, Hanyang University, Seoul, Republic of Korea.; Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Jazyk: angličtina
Zdroj: Animal cells and systems [Anim Cells Syst (Seoul)] 2022 Jan 12; Vol. 25 (6), pp. 358-368. Date of Electronic Publication: 2022 Jan 12 (Print Publication: 2021).
DOI: 10.1080/19768354.2021.2019109
Abstrakt: Human endogenous retroviruses (HERVs) are 'fossil viruses' that resulted from stable integrations of exogenous retroviruses throughout evolution. HERVs are defective and do not produce infectious viral particles. However, some HERVs retain a limited coding capacity and produce retroviral transcripts and proteins, which function in human developmental process and various pathologies, including many cancers and neurological diseases. Recently, it has been reported that HERVs are differently expressed in COVID-19 disease caused by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we discuss the molecular structure and function of HERV ENV proteins, particularly syncytins, and their conventional roles in human development and diseases, and potential involvement in COVID-19 regarding the newly reported mental symptoms. We also address COVID-19 vaccine-related infertility concerns arising from the similarity of syncytin with the spike protein of SARS-CoV-2, which have been proved invalid.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze: MEDLINE
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