Epithelial-Cadherin Expression Is Associated With Better Recurrence-Free and Overall Survival in Invasive Lobular Breast Cancer in Mexican Women.

Autor:	Fernandez-Ferreira R; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico., Dorantes-Heredia R; Service of Anatomical Pathology, Medica Sur Clinic & Foundation, Mexico City, Mexico., Motola-Kuba D; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico., Ruiz-Morales JM; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico., Alvarado-Luna G; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico., Kinney-Novelo IM; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico., Munoz-Montano WR; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico., Fuentes-Calvo KJ; Oncology Medicine Department, Comprehensive Oncology Center 'Diana Laura Riojas de Colosio', Medica Sur Clinic & Foundation, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	World journal of oncology [World J Oncol] 2021 Dec; Vol. 12 (6), pp. 214-224. Date of Electronic Publication: 2021 Dec 28.
DOI:	10.14740/wjon1426
Abstrakt:	Background: There are different clinicopathological characteristics that are associated with the prognosis in patients with breast cancer. To date, the prognostic valor of for epithelial cadherin (E cadherin) expression in invasive lobular breast cancer remains unknown. Methods: A retrospective single-center study that included 207 patients with primary invasive lobular breast cancer was conducted. The primary outcome was to report the correlation of the different clinical pathological characteristics including the expression of epithelial-cadherin (E-cadherin) in invasive lobular breast cancer in Mexican women with recurrence-free survival (RFS) and overall survival (OS). Results: After 11 years of follow-up of patients with invasive lobular breast cancer, RFS was 89.4% and OS of 96.1%. The best prognosis in RFS was in patients with negative nodes 95.2% (P = 0.0001) and OS was 98.6-100% (P = 0.0001). Regarding tumor size, an RFS of 98.3% was observed in those measuring ≤ 2 cm (P = 0.0001) and OS of 99.2% (P = 0.0001). Negative Her2 was related to an RFS of 92.1% (P = 0.0001), and had better OS of 98.3% (P = 0.0001). Ki67 proliferation index ≤ 14% was associated with an RFS of 93.2% (P = 0.005). Negative lymph vascular invasion (LVI) increases the RFS of 91.8% (P = 0.032). The rate of positive expression of E-cadherin was associated with an increase in the RFS of 97.4%, with a mean of 128.6 ± 2.4 months (95% confidence interval (CI): 123.75 - 133.45 months) compared to the absence of expression E-cadherin: signal log ratio (SLR) 68.9%, a mean of 95 ± 6 months (95% CI: 83.28 - 106.88 months), P <0.001. When the OS was analyzed, the presence of E-cadherin expression increased the OS of 100% vs. 86.9% with the absence, P = 0.015. Conclusions: The prognostic impact of the different clinicopathological characteristics known worldwide was confirmed. Results of the analysis in the presented study indicate that positive expression of E-cadherin correlates with an improvement in OS and RFS in invasive lobular breast cancer in Mexican women. Competing Interests: The authors have no conflict of interest to declare. (Copyright 2021, Fernandez-Ferreira et al.)
Databáze:	MEDLINE
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