Self-rated family health history knowledge among All of Us program participants.

Autor: Hull LE; Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA. Electronic address: lhull@mgh.harvard.edu., Natarajan P; Department of Medicine, Harvard Medical School, Boston, MA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA. Electronic address: pnatarajan@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2022 Apr; Vol. 24 (4), pp. 955-961. Date of Electronic Publication: 2022 Jan 17.
DOI: 10.1016/j.gim.2021.12.006
Abstrakt: Purpose: Disparities in access to genetics services are well-documented. Family health history is routinely used to determine whether patients should be screened for heritable conditions. We sought to explore variation in levels of self-rated family health history knowledge as a possible contributer to this disparity.
Methods: We performed a cross-sectional analysis of survey data from the All of Us Research Program. We compared the characteristics of participants who reported "None," "Some", and "A lot" of family health history knowledge using multinomial logistic regression.
Results: Self-rated family health history data were available for 116,799 participants. A minority of survey participants (37%) endorsed "A lot" of knowledge about their family health history (n = 43,661). Most participants (60%) endorsed "Some" family health history knowledge (n = 69,914) and 3% (n = 3224) endorsed "None." In adjusted analyses, those who indicated "Some" family health history knowledge or "None" were more likely to be assigned male sex at birth, identify as possible gender and sexual minorities, have a self-reported race other than White, have a lower household annual income (<$25,000), or report lower educational attainment (Conclusion: Family health history knowledge may be limited, especially among traditionally underserved populations.
Competing Interests: Conflict of Interest Leland E. Hull declares no conflict of interest. Pradeep Natarajan reports grant support from Amgen, Apple, AstraZeneca, and Boston Scientific; consulting income from Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Genentech, and Novartis; and spousal employment at Vertex, which are all unrelated to the current work.
(Copyright © 2021 American College of Medical Genetics and Genomics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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