Synthesis of a Novel, Biocompatible and Bacteriostatic Borosiloxane Composition with Silver Oxide Nanoparticles.

Autor: Chausov DN; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Smirnova VV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Burmistrov DE; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Sarimov RM; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Kurilov AD; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Astashev ME; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Uvarov OV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Dubinin MV; Mari State University, 424000 Yoshkar-Ola, Russia., Kozlov VA; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.; Bauman Moscow State Technical University, 105005 Moscow, Russia., Vedunova MV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.; The Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603105 Nizhny Novgorod, Russia., Rebezov MB; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.; V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences, 109316 Moscow, Russia., Semenova AA; V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences, 109316 Moscow, Russia., Lisitsyn AB; V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences, 109316 Moscow, Russia., Gudkov SV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.; The Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603105 Nizhny Novgorod, Russia.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2022 Jan 11; Vol. 15 (2). Date of Electronic Publication: 2022 Jan 11.
DOI: 10.3390/ma15020527
Abstrakt: Microbial antibiotic resistance is an important global world health problem. Recently, an interest in nanoparticles (NPs) of silver oxides as compounds with antibacterial potential has significantly increased. From a practical point of view, composites of silver oxide NPs and biocompatible material are of interest. A borosiloxane (BS) can be used as one such material. A composite material combining BS and silver oxide NPs has been synthesized. Composites containing BS have adjustable viscoelastic properties. The silver oxide NPs synthesized by laser ablation have a size of ~65 nm (half-width 60 nm) and an elemental composition of Ag 2 O. The synthesized material exhibits strong bacteriostatic properties against E. coli at a concentration of nanoparticles of silver oxide more than 0.01%. The bacteriostatic effect depends on the silver oxide NPs concentration in the matrix. The BS/silver oxide NPs have no cytotoxic effect on a eukaryotic cell culture when the concentration of nanoparticles of silver oxide is less than 0.1%. The use of the resulting composite based on BS and silver oxide NPs as a reusable dry disinfectant is due to its low toxicity and bacteriostatic activity and its characteristics are not inferior to the medical alloy nitinol.
Databáze: MEDLINE
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