| Autor: |
Anicescu MC; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Dinu-Pîrvu CE; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Talianu MT; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Ghica MV; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Anuța V; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Prisada RM; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Nicoară AC; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania., Popa L; Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 020950 Bucharest, Romania. |
| Abstrakt: |
The present study brings to attention a method to develop salicylic acid-based oil in water (O/W) microemulsions using a tensioactive system based on Tween 80, lecithin, and propylene glycol (PG), enriched with a vegetable oat oil phase and hyaluronic acid. The systems were physically characterized and the Quality by design approach was applied to optimize the attributes of microemulsions using Box-Behnken modeling, combined with response surface methodology. For this purpose, a 3 3 fractional factorial design was selected. The effect of independent variables namely X1: Tween 80/PG (%), X2: Lecithin (%), X3: Oil phase (%) was analyzed considering their impact upon the internal structure and evaluated parameters chosen as dependent factors: viscosity, mean droplet size, and work of adhesion. A high viscosity, a low droplet size, an adequate wettability-with a reduced mechanical work-and clarity were considered as desirable for the optimal systems. It was found that the optimal microemulsion which complied with the established conditions was based on: Tween 80/PG 40%, lecithin 0.3%, oat oil 2%, salicylic acid 0.5%, hyaluronic acid 1%, and water 56.2%. The response surface methodology was considered an appropriate tool to explain the impact of formulation factors on the physical properties of microemulsions, offering a complex pattern in the assessment of stability and quality attributes for the optimized formulation. |
