| Autor: |
Santini M; Department for Adult Intensive Care and Neuroinfections, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia., Haberle S; Institute of Emergency Medicine Krapina-Zagorje County, 49000 Krapina, Croatia., Židovec-Lepej S; Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Savić V; Poultry Center, Croatian Veterinary Institute, 10000 Zagreb, Croatia., Kusulja M; Department for Emergency Medicine, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Papić N; Department for Viral Hepatitis, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Višković K; Department for Radiology and Ultrasound Diagnostics, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Župetić I; Department for Radiology and Ultrasound Diagnostics, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Savini G; OIE Reference Center for West Nile Disease, Department of Virology, Istituto Zooprofilattico Sperimentale 'G. Caporale', 64100 Teramo, Italy., Barbić L; Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine of University of Zagreb, 10000 Zagreb, Croatia., Tabain I; Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia., Kutleša M; Department for Adult Intensive Care and Neuroinfections, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia., Krajinović V; Department for Adult Intensive Care and Neuroinfections, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia., Potočnik-Hunjadi T; Department of Infectious Diseases, Varazdin General Hospital, 42000 Varazdin, Croatia., Dvorski E; Department of Infectious Diseases, Varazdin General Hospital, 42000 Varazdin, Croatia., Butigan T; Department of Infectious Diseases, Varazdin General Hospital, 42000 Varazdin, Croatia., Kolaric-Sviben G; Department of Infectious Diseases, General Hospital 'Dr Tomislav Bardek', 48000 Koprivnica, Croatia., Stevanović V; Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine of University of Zagreb, 10000 Zagreb, Croatia., Gorenec L; Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Grgić I; Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Glavač F; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia., Mehmedović A; Department for Radiology and Ultrasound Diagnostics, University Hospital for Infectious Diseases 'Dr Fran Mihaljević', 10000 Zagreb, Croatia., Listeš E; Laboratory for Diagnostics, Croatian Veterinary Institute, Veterinary Institute Split, 21000 Split, Croatia., Vilibić-Čavlek T; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.; Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia. |
| Abstrakt: |
West Nile Virus Neuroinvasive Disease (WNV NID) requires prolonged intensive care treatment, resulting in high mortality and early disability. Long-term results are lacking. We have conducted an observational retrospective study with a prospective follow-up of WNV NID patients treated at the Intensive Care Unit (ICU), University Hospital for Infectious Diseases, Zagreb, Croatia, 2013-2018. Short-term outcomes were vital status, length of stay (LOS), modified Rankin Scale (mRS), and disposition at discharge. Long-term outcomes were vital status and mRS at follow-up. Twenty-three patients were identified, 78.3% males, median age 72 (range 33-84) years. Two patients (8.7%) died in the ICU, with no lethal outcomes after ICU discharge. The median ICU LOS was 19 days (range 5-73), and the median hospital LOS was 34 days (range 7-97). At discharge, 15 (65.2%) patients had moderate to severe/mRS 3-5, 6 (26.0%) had slight disability/mRS 2-1, no patients were symptom-free/mRS 0. Ten (47.6%) survivors were discharged to rehabilitation facilities. The median time to follow-up was nine months (range 6-69). At follow-up, seven patients died (30.5%), five (21.7%) had moderate to severe/mRS 3-5, one (4.3%) had slight disability/mRS 2-1, six (26.1%) had no symptoms/mRS 0, and four (17.4%) were lost to follow-up. Briefly, ten (43.5%) survivors improved their functional status, one (4.3%) was unaltered, and one (4.3%) aggravated. In patients with severe WNV NID, intensive treatment in the acute phase followed by inpatient rehabilitation resulted in significant recovery of functional status after several months. |
