Renoprotection of Selected Antioxidant-Rich Foods (Water Spinach and Red Grape) and Probiotics in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats.

Autor: Sarwar S; Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh., Hossain MJ; Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh., Irfan NM; Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh.; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52246, USA.; Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA., Ahsan T; Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh., Arefin MS; Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh., Rahman A; Department of Pathology, Dhaka Medical College and Hospital, Dhaka 1000, Bangladesh., Alsubaie A; Department of Physics, College of Khurma, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Alharthi B; Department of Biology, University College of Al Khurmah, Taif University, PO. Box 11099, Taif 21944, Saudi Arabia., Khandaker MU; Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Bandar Sunway, Petaling Jaya 47500, Malaysia., Bradley DA; Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Bandar Sunway, Petaling Jaya 47500, Malaysia.; Department of Physics, University of Surrey, Guilford GU2 7XH, UK., Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh., Islam SN; Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2022 Jan 03; Vol. 12 (1). Date of Electronic Publication: 2022 Jan 03.
DOI: 10.3390/life12010060
Abstrakt: Objectives: The current study investigated the curative effects of two selected antioxidant-rich foods (water spinach and red grape) and probiotics on the kidney exposed to nephrotoxicity induced by gentamicin.
Methods: A total of 30 Wistar Albino female rats equally divided into six groups were studied for seven days. Except for the normal control (NC) group, all groups received 80 mg/kg/day gentamicin (GEN) injection intra-peritoneally for seven days. NC and GEN groups received only regular diet. In the water spinach group (GEN + WS) and red grape (GEN + RG) groups, rats were provided with 20 g/rat/day of boiled water spinach and 5 mL/rat/day of red grape juice, respectively. The probiotic (GEN + P 4 ) and (GEN + P 8 ) groups received 4 × 10 9 and 8 × 10 9 viable bacteria, respectively. On the 8th day, all the rats were sacrificed to collect blood and kidney. Serum creatinine, urea, uric acid, malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) were analyzed. In addition, kidney histopathology was taken for final observation.
Results: Both antioxidant-rich foods and probiotic (P 4 ) significantly ( p < 0.05) attenuated the GEN-induced oxidative and nitrosative stress and improved kidney function by lowering uremic toxin (serum creatinine, and uric acid) levels. Histopathological findings of kidney tissues of all groups were consistent with the biochemical findings.
Conclusion: The current preclinical study suggests that the consumption of antioxidant-rich foods might be a promising fighting option against gentamycin-induced nephrotoxicity and oxidative stress. However, extensive studies and clinical monitoring are immediately required to determine the appropriate probiotic doses and mechanism of action for such effects.
Databáze: MEDLINE
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