Oxysterols in the Immune Response to Bacterial and Viral Infections.

Autor: Foo CX; Translational Research Institute, Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia., Bartlett S; Translational Research Institute, Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia., Ronacher K; Translational Research Institute, Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.
Jazyk: angličtina
Zdroj: Cells [Cells] 2022 Jan 07; Vol. 11 (2). Date of Electronic Publication: 2022 Jan 07.
DOI: 10.3390/cells11020201
Abstrakt: Oxidized cholesterols, the so-called oxysterols, are widely known to regulate cholesterol homeostasis. However, more recently oxysterols have emerged as important lipid mediators in the response to both bacterial and viral infections. This review summarizes our current knowledge of selected oxysterols and their receptors in the control of intracellular bacterial growth as well as viral entry into the host cell and viral replication. Lastly, we briefly discuss the potential of oxysterols and their receptors as drug targets for infectious and inflammatory diseases.
Databáze: MEDLINE
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