| Autor: |
Teixeira QE; Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro 22790-710, Brazil., Ferreira DC; Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro 22790-710, Brazil., da Silva AMP; Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro 22790-710, Brazil., Gonçalves LS; Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro 22790-710, Brazil., Pires FR; Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro 22790-710, Brazil., Carrouel F; Health, Systemic, Process (P2S), UR 4129 Research Unit, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France., Bourgeois D; Health, Systemic, Process (P2S), UR 4129 Research Unit, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France., Sufiawati I; Department of Oral Medicine, Universitas Padjadjaran, Bandung 40132, Indonesia., Armada L; Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro 22790-710, Brazil. |
| Abstrakt: |
Persistent inflammatory responses in the elderly may act as modifiers on the progression and repair of chronic apical periodontitis lesions (CAPLs). While the involvement of IL-1β, IL-6 and TNF-α in inflammatory responses and, particularly, in CAPL has been documented, their expression in elderly patients needs to be further characterized. Therefore, the purpose of this study was to evaluate and compare the expressions of pro-inflammatory cytokines in CAPL from elderly individuals with young/middle-aged individuals. Thirty CAPL (15 cysts and 15 granulomas) from elderly patients (>60 years) and 30 CAPL (15 cysts and 15 granuloma) from young/middle-aged individuals (20-56 years) were selected. Immunohistochemical reactions were performed against IL-1β, IL-6 and TNF-α. The slides were subdivided into five high-magnification fields and analyzed. The number of positive stains was evaluated for each antibody. There was no significant difference between the cytokines when the cysts and granuloma were compared in the two groups. In the young/middle-aged, only IL-1β showed a difference and was significantly higher in granulomas ( p = 0.019). CAPL pro-inflammatory cytokine levels in the elderly were significantly higher than in young/middle-aged individuals ( p < 0.05). The pro-inflammatory cytokines IL-1β, IL-6 and TNF-α were significantly higher in CAPL in the elderly compared with the young/middle-aged group. Further elaborate research studies/analyses to elucidate the reasons for and consequences of inflammation in the elderly are recommended. |
