Transmission from vaccinated individuals in a large SARS-CoV-2 Delta variant outbreak.

Autor:	Siddle KJ; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: kjsiddle@broadinstitute.org., Krasilnikova LA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Moreno GK; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Schaffner SF; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Vostok J; Massachusetts Department of Public Health, Boston, MA 02199, USA., Fitzgerald NA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Lemieux JE; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Barkas N; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Loreth C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Specht I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA., Tomkins-Tinch CH; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Paull JS; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Schaeffer B; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Taylor BP; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Loftness B; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Johnson H; Massachusetts Department of Public Health, Boston, MA 02199, USA., Schubert PL; Massachusetts Department of Public Health, Boston, MA 02199, USA., Shephard HM; Massachusetts Department of Public Health, Boston, MA 02199, USA; Applied Epidemiology Fellowship, Council of State and Territorial Epidemiologists, Atlanta, GA 30345, USA., Doucette M; Massachusetts Department of Public Health, Boston, MA 02199, USA., Fink T; Massachusetts Department of Public Health, Boston, MA 02199, USA., Lang AS; Massachusetts Department of Public Health, Boston, MA 02199, USA., Baez S; Massachusetts Department of Public Health, Boston, MA 02199, USA., Beauchamp J; Massachusetts Department of Public Health, Boston, MA 02199, USA., Hennigan S; Massachusetts Department of Public Health, Boston, MA 02199, USA., Buzby E; Massachusetts Department of Public Health, Boston, MA 02199, USA., Ash S; Massachusetts Department of Public Health, Boston, MA 02199, USA., Brown J; Massachusetts Department of Public Health, Boston, MA 02199, USA., Clancy S; Massachusetts Department of Public Health, Boston, MA 02199, USA., Cofsky S; Massachusetts Department of Public Health, Boston, MA 02199, USA., Gagne L; Massachusetts Department of Public Health, Boston, MA 02199, USA., Hall J; Massachusetts Department of Public Health, Boston, MA 02199, USA., Harrington R; Massachusetts Department of Public Health, Boston, MA 02199, USA., Gionet GL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., DeRuff KC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Vodzak ME; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Adams GC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Dobbins ST; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Slack SD; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Reilly SK; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Anderson LM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Cipicchio MC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., DeFelice MT; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Grimsby JL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Anderson SE; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Blumenstiel BS; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Meldrim JC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Rooke HM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Vicente G; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Smith NL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Messer KS; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Reagan FL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Mandese ZM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Lee MD; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Ray MC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Fisher ME; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Ulcena MA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Nolet CM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., English SE; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Larkin KL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Vernest K; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Chaluvadi S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Arvidson D; Barnstable County Department of Health and the Environment, Barnstable, MA 02630, USA., Melchiono M; Barnstable County Department of Health and the Environment, Barnstable, MA 02630, USA., Covell T; Barnstable County Department of Health and the Environment, Barnstable, MA 02630, USA., Harik V; Barnstable County Department of Human Services, Barnstable, MA 02630, USA., Brock-Fisher T; Community Tracing Collaborative, Commonwealth of Massachusetts, Boston, MA 02199, USA., Dunn M; Community Tracing Collaborative, Commonwealth of Massachusetts, Boston, MA 02199, USA., Kearns A; Community Tracing Collaborative, Commonwealth of Massachusetts, Boston, MA 02199, USA., Hanage WP; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Bernard C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Philippakis A; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Lennon NJ; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Gabriel SB; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Gallagher GR; Massachusetts Department of Public Health, Boston, MA 02199, USA., Smole S; Massachusetts Department of Public Health, Boston, MA 02199, USA., Madoff LC; Massachusetts Department of Public Health, Boston, MA 02199, USA., Brown CM; Massachusetts Department of Public Health, Boston, MA 02199, USA., Park DJ; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., MacInnis BL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Massachusetts Consortium for Pathogen Readiness, Boston, MA 02115, USA. Electronic address: bronwyn@broadinstitute.org., Sabeti PC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Massachusetts Consortium for Pathogen Readiness, Boston, MA 02115, USA.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2022 Feb 03; Vol. 185 (3), pp. 485-492.e10. Date of Electronic Publication: 2021 Dec 23.
DOI:	10.1016/j.cell.2021.12.027
Abstrakt:	An outbreak of over 1,000 COVID-19 cases in Provincetown, Massachusetts (MA), in July 2021-the first large outbreak mostly in vaccinated individuals in the US-prompted a comprehensive public health response, motivating changes to national masking recommendations and raising questions about infection and transmission among vaccinated individuals. To address these questions, we combined viral genomic and epidemiological data from 467 individuals, including 40% of outbreak-associated cases. The Delta variant accounted for 99% of cases in this dataset; it was introduced from at least 40 sources, but 83% of cases derived from a single source, likely through transmission across multiple settings over a short time rather than a single event. Genomic and epidemiological data supported multiple transmissions of Delta from and between fully vaccinated individuals. However, despite its magnitude, the outbreak had limited onward impact in MA and the US overall, likely due to high vaccination rates and a robust public health response. Competing Interests: Declaration of interests P.C.S. is a co-founder of, shareholder in, and scientific advisor to Sherlock Biosciences, as well as a board member of and shareholder in Danaher Corporation. J.E.L. has received consulting fees from Sherlock Biosciences. A.P. is a venture partner at Google Ventures. W.P.H. is a member of the scientific advisory board of Biobot. Other authors report no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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