| Autor: |
Nagahawatta DP; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea., Kim HS; Department of Applied Research, National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101-gil, Janghang-eup, Seocheon 33662, Korea., Jee YH; Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 690-756, Korea., Jayawardena TU; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea., Ahn G; Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea., Namgung J; Graduate School of Fisheries Sciences, Hokkaido University, 3-1-1 Minato, Hakodate, Hokkaido 041-8611, Japan., Yeo IK; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea., Sanjeewa KKA; Department of Biosystems Technology, Faculty of Technology, University of Sri Jayewardenepura, Pitipana, Homagama 10206, Sri Lanka., Jeon YJ; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea.; Marine Science Institute, Jeju National University, Jeju 63333, Korea. |
| Abstrakt: |
Sargassum horneri is an invasive brown seaweed that grows along the shallow coastal areas of the Korean peninsula, which are potentially harmful to fisheries and natural habitats in the areas where it is accumulated. Therefore, the author attempted to evaluate the anti-inflammatory mechanism of Sargachromenol isolated from S. horneri against particulate matter (PM)-stimulated RAW 264.7 macrophages. PM is a potent inducer of respiratory diseases such as lung dysfunctions and cancers. In the present study, the anti-inflammatory properties of Sargachromenol were validated using enzyme-linked immunosorbent assay (ELISA), Western blots, and RT-qPCR experiments. According to the results, Sargachromenol significantly downregulated the PM-induced proinflammatory cytokines, Prostaglandin E2 (PGE2), and Nitric Oxide (NO) secretion via blocking downstream activation of Toll-like receptor (TLR)-mediated nuclear factor kappa B (NF-κB) and MAPKs phosphorylation. Thus, Sargachromenol is a potential candidate for innovation in various fields including pharmaceuticals, cosmeceuticals, and functional food. |
