| Autor: |
Nguyen NT; Faculty of Medicine-Pharmacy, Tra Vinh University, Tra Vinh City 87000, Vietnam., Bui QA; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 71500, Vietnam., Nguyen HHN; Faculty of Biology and Biotechnology, University of Science-Vietnam National University, Ho Chi Minh City 72700, Vietnam., Nguyen TT; Faculty of Medicine-Pharmacy, Tra Vinh University, Tra Vinh City 87000, Vietnam., Ly KL; Faculty of Medicine-Pharmacy, Tra Vinh University, Tra Vinh City 87000, Vietnam., Tran HLB; Faculty of Biology and Biotechnology, University of Science-Vietnam National University, Ho Chi Minh City 72700, Vietnam., Doan VN; Faculty of Biology and Biotechnology, University of Science-Vietnam National University, Ho Chi Minh City 72700, Vietnam., Nhi TTY; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71500, Vietnam.; Institute of Environmental Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 72800, Vietnam., Nguyen NH; German Vietnamese Technology Center, HCMC University of Food Industry, Ho Chi Minh City 72000, Vietnam., Nguyen NH; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 71500, Vietnam., Tran NQ; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 71500, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71500, Vietnam., Nguyen DT; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 71500, Vietnam. |
| Abstrakt: |
Nanosized multi-drug delivery systems provide synergistic effects between drugs and bioactive compounds, resulting in increased overall efficiency and restricted side effects compared to conventional single-drug chemotherapy. In this study, we develop an amphiphilic heparin-poloxamer P403 (HP403) nanogel that could effectively co-load curcuminoid (Cur) and cisplatin hydrate (CisOH) (HP403@CisOH@Cur) via two loading mechanisms. The HP403 nanogels and HP403@CisOH@Cur nanogels were closely analyzed with 1 H-NMR spectroscopy, FT-IR spectroscopy, TEM, and DLS, exhibiting high stability in spherical forms. In drug release profiles, accelerated behavior of Cur and CisOH at pH 5.5 compared with neutral pH was observed, suggesting effective delivery of the compounds in tumor sites. In vitro studies showed high antitumor activity of HP403@CisOH@Cur nanogels, while in vivo assays showed that the dual-drug platform prolonged the survival time of mice and prevented tail necrosis. In summary, HP403@CisOH@Cur offers an intriguing strategy to achieve the cisplatin and curcumin synergistic effect in a well-designed delivery platform that increases antitumor effectiveness and overcomes undesired consequences caused by cisplatin in breast cancer treatment. |
