| Autor: |
Tejo-Otero A; Centre CIM, Universitat Politècnica de Catalunya (CIM UPC), Carrer de Llorens i Artigas, 12, 08028 Barcelona, Spain., Fenollosa-Artés F; Centre CIM, Universitat Politècnica de Catalunya (CIM UPC), Carrer de Llorens i Artigas, 12, 08028 Barcelona, Spain.; Departament of Mechanical Engineering, Barcelona School of Industrial Engineering (ETSEIB), Universitat Politècnica de Catalunya, Av. Diagonal, 647, 08028 Barcelona, Spain., Achaerandio I; Department d'Enginyeria Agroalimentària i Biotecnologia, Escola d'Enginyeria Agroalimentària i de Biosistemes de Barcelona, Universitat Politècnica de Catalunya, Carrer Esteve Terradas, 8, 08860 Barcelona, Spain., Rey-Vinolas S; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri Reixac 15-21, 08028 Barcelona, Spain., Buj-Corral I; Departament of Mechanical Engineering, Barcelona School of Industrial Engineering (ETSEIB), Universitat Politècnica de Catalunya, Av. Diagonal, 647, 08028 Barcelona, Spain., Mateos-Timoneda MÁ; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri Reixac 15-21, 08028 Barcelona, Spain.; Bioengineering Institute of Technology, Universitat Internacional de Catalunya (UIC), c/Josep Trueta s/n, 08195 Barcelona, Spain., Engel E; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri Reixac 15-21, 08028 Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales y Nanotecnología (CIBER-BBN), 28029 Madrid, Spain.; IMEM-BRT Group, Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain. |
| Abstrakt: |
With the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promising solution to simulate biological bodies. For this reason, to advance in the state-of-the-art a wide range of organs (e.g., liver, heart, kidney as well as brain) and hydrogels (e.g., agarose, polyvinyl alcohol -PVA-, Phytagel -PHY- and methacrylate gelatine -GelMA-) were tested regarding their mechanical properties. For that, viscoelastic behavior, hardness, as well as a non-linear elastic mechanical response were measured. It was seen that there was a significant difference among the results for the different mentioned soft tissues. Some of them appear to be more elastic than viscous as well as being softer or harder. With all this information in mind, a correlation between the mechanical properties of the organs and the different materials was performed. The next conclusions were drawn: (1) to mimic the liver, the best material is 1% wt agarose; (2) to mimic the heart, the best material is 2% wt agarose; (3) to mimic the kidney, the best material is 4% wt GelMA; and (4) to mimic the brain, the best materials are 4% wt GelMA and 1% wt agarose. Neither PVA nor PHY was selected to mimic any of the studied tissues. |
