| Autor: |
Martinez RM; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Oseliero Filho PL; Department of Applied Physics, Physics Institute, University of São Paulo, São Paulo 05508-000, Brazil., Gerbelli BB; Center of Natural and Human Sciences, Federal University of ABC, Santo André 09210-170, Brazil., Magalhães WV; Research & Development Laboratory-Chemyunion Ltd., Sorocaba 18103-065, Brazil., Velasco MVR; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., da Silva Lannes SC; Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., de Oliveira CLP; Department of Experimental Physics, Physics Institute, University of São Paulo, São Paulo 05508-000, Brazil., Rosado C; CBIOS-Universidade Lusófona's Research Center for Biosciences and Health Technologies, 1749-024 Lisbon, Portugal., Baby AR; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil. |
| Abstrakt: |
Candelilla wax (CW) and 12-hydroxystearic acid (12HSA) are classic solid-fiber-matrix organogelators. Despite the high number of studies using those ingredients in oily systems, there is scarce literature using a mixture of oil and antioxidants. Vitamin E (VE) is an important candidate for its lipophilicity and several applications on pharmaceutical, cosmetics, and food industries. In this work, we investigated the influences of mixtures between vegetable oil (VO) and VE on the microstructures and rheological properties of CW and 12HSA organogels. A weak gel (G''/G' > 0.1) with a shear-thinning behavior was observed for all samples. The presence of VE impacted the gel strength and the phase transition temperatures in a dose-dependent pattern. Larger and denser packed crystals were seen for 12HSA samples, while smaller and more dispersed structures were obtained for CW organogels. The results obtained in this work allowed the correlation of the structural and mechanical properties of the organogels, which plays an important role in the physical-chemical characteristics of these materials. |
