Agricultural exposure and risk of soft tissue sarcomas and gastrointestinal stromal sarcoma in the AGRIculture and CANcer (AGRICAN) cohort.

Autor: Renier M; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France., Busson A; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France., Boulanger M; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France.; Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Piel C; INSERM, Bordeaux Population Health Research Center, Team EPICENE, Université de Bordeaux, Bordeaux, France., Pons R; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France.; Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Tual S; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France.; Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Amadéo B; INSERM, Bordeaux Population Health Research Center, Team EPICENE, Université de Bordeaux, Bordeaux, France.; FRANCIM, Réseau National du Registre des Cancers, Toulouse, France., Meryet-Figuiere M; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France.; Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Marcotullio E; Caisse Centrale de la Mutualité Sociale Agricole, Echelon National Santé Sécurité au Travail, Bagnolet, France., Clin B; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France.; Occupational Health Department, CHU de Caen, Caen, France., Baldi I; INSERM, Bordeaux Population Health Research Center, Team EPICENE, Université de Bordeaux, Bordeaux, France.; Public Health Unit, Occupational Medicine and Pathology Department, CHU de Bordeaux, Bordeaux, France., Lebailly P; INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.; UFR de Santé, Université de Caen Normandie, Caen, France.; Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2022 Jun 01; Vol. 150 (11), pp. 1792-1803. Date of Electronic Publication: 2022 Jan 29.
DOI: 10.1002/ijc.33936
Abstrakt: Sarcomas are a heterogeneous group of tumors whose incidence is nearly 5 per 100 000 inhabitants in Europe. Their causes are poorly understood, although occupational exposures (especially farming and pesticides) are suspected. The AGRICAN cohort is a prospective study of 181 842 individuals enrolled in 2005 to 2007 who completed an enrolment questionnaire with data on lifelong agricultural exposure. Associations between agricultural exposure and sarcoma overall, gastrointestinal stromal tumors (GIST) and myomatous and fibrous sarcoma together, were analyzed with a Cox model. Until 2015, 188 incident cases of sarcoma were identified. Increased risks were observed (a) among cattle farmers working <10 years (HR <10years  = 2.45, 95% CI 1.36-4.43) and breeding ≥50 livestock (HR ≥50animals  = 3.84, 95% CI 1.60-9.22), especially if involved in animal care and building disinfection, (b) in greenhouse production (HR = 1.82, 95% CI 1.01-3.30) and (c) in field-grown vegetable production (HR = 1.49, 95% CI 0.96-2.32). Concerning histological subtypes, GIST were positively associated with pesticide use in vineyards (HR = 2.24, 95% CI 0.95-5.30). For myomatous and fibrous sarcoma, the only increase was seen in field-grown vegetable production (HR = 2.37, 95% CI 1.16-4.85). In AGRICAN, the risk of sarcomas was increased in several farming activities with differences according to histological subtype.
(© 2022 UICC.)
Databáze: MEDLINE
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