Clinical outcome measures and their evidence base in degenerative cervical myelopathy: a systematic review to inform a core measurement set (AO Spine RECODE-DCM).

Autor:	Yanez Touzet A; School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, Manchester, UK., Bhatti A; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Dohle E; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Bhatti F; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Lee KS; Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK., Furlan JC; Department of Medicine, Division of Physical Medicine and Rehabilita, University of Toronto, Toronto, Ontario, Canada.; Division of Physical Medicine and Rehabilitation, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada.; KITE Research Institute, University Health Network, Toronto, Ontario, Canada., Fehlings MG; Division of Neurosurgery and Spinal Program, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., Harrop JS; Thomas Jefferson University, Jefferson Health System, St Louis, Philadelphia, USA., Zipser CM; Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland., Rodrigues-Pinto R; Spinal Unit (UVM), Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal., Milligan J; Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada., Sarewitz E; Myelopathy.org, Cambridge, UK., Curt A; Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland., Rahimi-Movaghar V; Academic Department of Neurological Surgery, Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran., Aarabi B; Division of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA., Boerger TF; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Tetreault L; Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., Chen R; Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.; Krembil Research Institute, Toronto, Ontario, Canada., Guest JD; Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA., Kalsi-Ryan S; KITE Research Institute, University Health Network, Toronto, Ontario, Canada., McNair AG; Centre for Surgical Research, Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, Avon, UK.; GI Surgery, North Bristol NHS Trust, Bristol, UK., Kotter M; Department of Clinical Neurosurgery, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, Ann McLaren Laboratory of Regenerative Medicine, Cambridge, UK., Davies B; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK bd375@cam.ac.uk.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Jan 19; Vol. 12 (1), pp. e057650. Date of Electronic Publication: 2022 Jan 19.
DOI:	10.1136/bmjopen-2021-057650
Abstrakt:	Objectives: To evaluate the measurement properties of outcome measures currently used in the assessment of degenerative cervical myelopathy (DCM) for clinical research. Design: Systematic review DATA SOURCES: MEDLINE and EMBASE were searched through 4 August 2020. Eligibility Criteria: Primary clinical research published in English and whose primary purpose was to evaluate the measurement properties or clinically important differences of instruments used in DCM. Data Extraction and Synthesis: Psychometric properties and clinically important differences were both extracted from each study, assessed for risk of bias and presented in accordance with the Consensus-based Standards for the selection of health Measurement Instruments criteria. Results: Twenty-nine outcome instruments were identified from 52 studies published between 1999 and 2020. They measured neuromuscular function (16 instruments), life impact (five instruments), pain (five instruments) and radiological scoring (five instruments). No instrument had evaluations for all 10 measurement properties and <50% had assessments for all three domains (ie, reliability, validity and responsiveness). There was a paucity of high-quality evidence. Notably, there were no studies that reported on structural validity and no high-quality evidence that discussed content validity. In this context, we identified nine instruments that are interpretable by clinicians: the arm and neck pain scores; the 12-item and 36-item short form health surveys; the Japanese Orthopaedic Association (JOA) score, modified JOA and JOA Cervical Myelopathy Evaluation Questionnaire; the neck disability index; and the visual analogue scale for pain. These include six scores with barriers to application and one score with insufficient criterion and construct validity. Conclusions: This review aggregates studies evaluating outcome measures used to assess patients with DCM. Overall, there is a need for a set of agreed tools to measure outcomes in DCM. These findings will be used to inform the development of a core measurement set as part of AO Spine RECODE-DCM. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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