Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study.

Autor: Buckle GC; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 505 Parnassus Ave, M1296, San Francsico, CA, 94143, USA. geoffrey.buckle@ucsf.edu., Mrema A; Ocean Road Cancer Institute, Dar es Salaam, Tanzania., Mwachiro M; Tenwek Hospital, Bomet, Kenya., Ringo Y; Muhimbili National Hospital, Dar es Salaam, Tanzania., Selekwa M; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Mulima G; Kamuzu Central Hospital, Lilongwe, Malawi., Some FF; Moi University School of Medicine, Eldoret, Kenya., Mmbaga BT; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; Kilimanjaro Christian Medical University College, Moshi, Tanzania., Mody GN; University of North Carolina, Chapel Hill, USA., Zhang L; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 505 Parnassus Ave, M1296, San Francsico, CA, 94143, USA., Paciorek A; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 505 Parnassus Ave, M1296, San Francsico, CA, 94143, USA., Akoko L; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Ayuo P; Moi University School of Medicine, Eldoret, Kenya., Burgert S; Tenwek Hospital, Bomet, Kenya., Bukusi E; Kenya Medical Research Institute, Nairobi, Kenya., Charles A; University of North Carolina, Chapel Hill, USA., Chepkemoi W; Tenwek Hospital, Bomet, Kenya., Chesumbai G; Moi University School of Medicine, Eldoret, Kenya., Kaimila B; UNC-Project Malawi, Lilongwe, Malawi., Kenseko A; Moi Teaching and Referral Hospital, Eldoret, Kenya., Kibwana KS; Muhimbili National Hospital, Dar es Salaam, Tanzania., Koech D; Moi Teaching and Referral Hospital, Eldoret, Kenya., Macharia C; Tenwek Hospital, Bomet, Kenya., Moirana EN; Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Mushi BP; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Mremi A; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Mwaiselage J; Ocean Road Cancer Institute, Dar es Salaam, Tanzania., Mwanga A; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Ndumbalo J; Ocean Road Cancer Institute, Dar es Salaam, Tanzania., Nvakunga G; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Ngoma M; Ocean Road Cancer Institute, Dar es Salaam, Tanzania., Oduor M; Moi University School of Medicine, Eldoret, Kenya., Oloo M; Moi Teaching and Referral Hospital, Eldoret, Kenya., Opakas J; Moi Teaching and Referral Hospital, Eldoret, Kenya., Parker R; Tenwek Hospital, Bomet, Kenya.; Warren Alpert School of Medicine at Brown University, Providence, RI, USA., Seno S; Moi Teaching and Referral Hospital, Eldoret, Kenya., Salima A; UNC-Project Malawi, Lilongwe, Malawi., Servent F; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Wandera A; Moi University School of Medicine, Eldoret, Kenya., Westmoreland KD; University of North Carolina, Chapel Hill, USA.; UNC-Project Malawi, Lilongwe, Malawi., White RE; Tenwek Hospital, Bomet, Kenya.; Warren Alpert School of Medicine at Brown University, Providence, RI, USA., Williams B; University of North Carolina, Chapel Hill, USA., Mmbaga EJ; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Van Loon K; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 505 Parnassus Ave, M1296, San Francsico, CA, 94143, USA.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2022 Jan 19; Vol. 22 (1), pp. 82. Date of Electronic Publication: 2022 Jan 19.
DOI: 10.1186/s12885-021-09124-5
Abstrakt: Background: Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of diagnosis. Several palliative interventions for ESCC are currently in use within the region, including chemotherapy, radiation therapy with and without chemotherapy, and esophageal stenting with self-expandable metallic stents; however, the comparative effectiveness of these interventions in a low resource setting has yet to be examined.
Methods: This prospective, observational, multi-center, open cohort study aims to describe the therapeutic landscape of ESCC in Eastern Africa and investigate the outcomes of different treatment strategies within the region. The 4.5-year study will recruit at a total of six sites in Kenya, Malawi and Tanzania (Ocean Road Cancer Institute and Muhimbili National Hospital in Dar es Salaam, Tanzania; Kilimanjaro Christian Medical Center in Moshi, Tanzania; Tenwek Hospital in Bomet, Kenya; Moi Teaching and Referral Hospital in Eldoret, Kenya; and Kamuzu Central Hospital in Lilongwe, Malawi). Treatment outcomes that will be evaluated include overall survival, quality of life (QOL) and safety. All patients (≥18 years old) who present to participating sites with a histopathologically-confirmed or presumptive clinical diagnosis of ESCC based on endoscopy or barium swallow will be recruited to participate. Key clinical and treatment-related data including standardized QOL metrics will be collected at study enrollment, 1 month following treatment, 3 months following treatment, and thereafter at 3-month intervals until death. Vital status and QOL data will be collected through mobile phone outreach.
Discussion: This study will be the first study to prospectively compare ESCC treatment strategies in Eastern Africa, and the first to investigate QOL benefits associated with different treatments in sub-Saharan Africa. Findings from this study will help define optimal management strategies for ESCC in Eastern Africa and other resource-limited settings and will serve as a benchmark for future research.
Trial Registration: This study was retrospectively registered with the ClinicalTrials.gov database on December 15, 2021,  NCT05177393 .
(© 2022. The Author(s).)
Databáze: MEDLINE
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