| Autor: |
Araújo CS; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil., Nery DA; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil., Oliveira AP; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil., Oliveira-Júnior RG; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil., Rolim LA; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil., Lopes NP; University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Silva MFS; Federal University of Ceará (UFC), Fortaleza, Ceará, Brazil., Pessoa CDÓ; Federal University of Ceará (UFC), Fortaleza, Ceará, Brazil., Braz-Filho R; State University of North Fluminense (UENF), Rio de Janeiro, Rio de Janeiro, Brazil., Dutra LM; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil., Tavares JF; Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil., Abreu LS; Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil., Silva MSD; Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil., Almeida JRGDS; Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of the San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil. |
| Abstrakt: |
A new nor- ent -kaurene diterpene and ten other compounds were isolated from Annona vepretorum stems, including four kaurene diterpenes, three alkamides, one sesquiterpene and two steroids. Their chemical structures were elucidated using spectroscopic methods, including 1D-, 2D-NMR, and HRESIMS. The absolute configuration of compounds 1 , 5 , 8 , 9 and 10 was confirmed by CD experiments. Compounds 1-5 and 8-10 were evaluated for cytotoxic activity using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT method, against three human carcinoma cell lines: human colon (HCT-116), glioblastoma (SF295) and prostate (PC3). However, all isolated compounds exhibited low cytotoxic activity. |
