Streamlining physiologically-based pharmacokinetic model design for intravenous delivery of nanoparticle drugs.

Autor: Le AD; Nanoscience & Microsystems Engineering, University of New Mexico, Albuquerque, New Mexico, USA., Wearing HJ; Department of Biology, Department of Mathematics & Statistics, University of New Mexico, Albuquerque, New Mexico, USA., Li D; School of Community Health Sciences, University of Nevada, Reno, Nevada, USA.
Jazyk: angličtina
Zdroj: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 Apr; Vol. 11 (4), pp. 409-424. Date of Electronic Publication: 2022 Feb 07.
DOI: 10.1002/psp4.12762
Abstrakt: Physiologically-based pharmacokinetic (PBPK) modeling for nanoparticles elucidates the nanoparticle drug's disposition in the body and serves a vital role in drug development and clinical studies. This paper offers a systematic and tutorial-like approach to developing a model structure and writing distribution ordinary differential equations based on asking binary questions involving the physicochemical nature of the drug in question. Further, by synthesizing existing knowledge, we summarize pertinent aspects in PBPK modeling and create a guide for building model structure and distribution equations, optimizing nanoparticle and non-nanoparticle specific parameters, and performing sensitivity analysis and model validation. The purpose of this paper is to facilitate a streamlined model development process for students and practitioners in the field.
(© 2022 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)
Databáze: MEDLINE
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