How common is ventilator-associated pneumonia after coronavirus disease 2019?
| Autor: | Wicky PH; Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat Hospital, Paris Diderot University., d'Humières C; AP-HP, Hôpital Bichat, Bacteriology.; UMR 1137, IAME, Université Paris Diderot, Paris, France., Timsit JF; Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat Hospital, Paris Diderot University.; UMR 1137, IAME, Université Paris Diderot, Paris, France. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in infectious diseases [Curr Opin Infect Dis] 2022 Apr 01; Vol. 35 (2), pp. 170-175. |
| DOI: | 10.1097/QCO.0000000000000817 |
| Abstrakt: | Purpose of Review: The first studies on COVID-19 patients with acute respiratory distress syndrome (ARDS) described a high rate of secondary bacterial ventilator-associated pneumonia (VAP). The specificity of VAP diagnoses in these patients are reviewed, including their actual rate. Recent Findings: Published studies described high rates of bacterial VAP among COVID-19 patients with ARDS, and these VAP episodes are usually severe and of specifically poor prognosis with high mortality. Indeed, Severe acute respiratory syndrome - coronavirus disease 19 (SARS-CoV2) infection elicits alterations that may explain a high risk of VAP. In addition, breaches in the aseptic management of patients might have occurred when the burden of care was heavy. In addition, VAP in these patients is more frequently suspected, and more often investigated with diagnostic tools based on molecular techniques. Summary: VAP is frequented and of particularly poor prognosis in COVID-19 patients with ARDS. It can be explained by SARS-CoV-2 pathophysiology, and also breaches in the aseptic procedures. In addition, tools based on molecular techniques allow an early diagnosis and unmask VAP usually underdiagnosed by traditional culture-based methods. The impact of molecular technique-based diagnostics in improving antibacterial therapy and COVID-19 prognosis remain to be evaluated. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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