Risk of Developing Type 2 Diabetes in Individuals With a Psychiatric Disorder: A Nationwide Register-Based Cohort Study.

Autor:	Lindekilde N; Department of Psychology, University of Southern Denmark, Odense, Denmark., Scheuer SH; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Diaz LJ; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Rubin KH; OPEN-Open Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark., Plana-Ripoll O; National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark., Henriksen JE; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark., Lasgaard M; DEFACTUM-Public Health & Health Services Research, Central Denmark Region, Aarhus, Denmark., Andersen GS; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Pouwer F; Department of Psychology, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2022 Mar 01; Vol. 45 (3), pp. 724-733.
DOI:	10.2337/dc21-1864
Abstrakt:	Objective: Previous studies have investigated the incidence of type 2 diabetes in individuals with psychiatric disorders, but most studies have focused on a specific psychiatric disorder or a selected sample. More population-based studies are needed to determine these associations in representative samples. We therefore aimed to determine these associations in a nationwide, register-based dynamic cohort study. Research Design and Methods: We analyzed data from 5,005,612 adults living in Denmark between 1995 and 2018, without prior diabetes. We investigated 10 different categories of psychiatric disorders and a composite group with any psychiatric disorder. Individuals with a psychiatric disorder were compared with individuals without using multivariable-adjusted Poisson regression to estimate incidence rate ratios (IRR) of type 2 diabetes. We modeled age-specific incidence rates (IR) for individuals with and without the specific psychiatric disorder. All models were stratified by sex. Results: In total, 334,739 individuals developed type 2 diabetes during follow-up. For all investigated categories of psychiatric disorders, we found increased IR of type 2 diabetes for individuals with versus those without a psychiatric disorder (IRR: men, 1.47 [95% CI 1.45-1.50]; women, 1.65 [95% CI 1.62-1.68]). When we examined age-specific IR, the largest differences were found in the younger population (<50 years). Conclusions: We found that the IR of type 2 diabetes was higher in individuals with a psychiatric disorder compared with individuals without a psychiatric disorder and particularly high in the younger people with a psychiatric disorder. New studies into the prevention and early detection of type 2 diabetes in these groups are warranted. (© 2022 by the American Diabetes Association.)
Databáze:	MEDLINE
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