Resting state functional connectivity provides mechanistic predictions of future changes in sedentary behavior.

Autor: Morris TP; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA. t.morris@northeastern.edu., Kucyi A; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA., Anteraper SA; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA., Geddes MR; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.; Brigham and Women's Hospital, Harvard Medical School, Cambridge, USA., Nieto-Castañon A; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA., Burzynska A; Department of Human Development and Family Studies, Colorado State University, Fort Collins, USA., Gothe NP; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, USA.; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Fanning J; Department of Health and Exercise Sciences, Wake Forrest University, Winston-Salem, NC, USA., Salerno EA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Whitfield-Gabrieli S; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Hillman CH; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA.; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, USA., McAuley E; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, USA.; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Kramer AF; Department of Psychology, Northeastern University, 435 ISEC, 360 Huntington Avenue, Boston, 02115, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jan 18; Vol. 12 (1), pp. 940. Date of Electronic Publication: 2022 Jan 18.
DOI: 10.1038/s41598-021-04738-y
Abstrakt: Sedentary behaviors are increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths worldwide. Understanding the mechanistic predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. It has been posited that humans have an innate attraction towards effort minimization and that inhibitory control is required to overcome this prepotent disposition. Consequently, we hypothesized that individual differences in the functional connectivity of brain regions implicated in inhibitory control and physical effort decision making at the beginning of an exercise intervention in older adults would predict the change in time spent sedentary over the course of that intervention. In 143 healthy, low-active older adults participating in a 6-month aerobic exercise intervention (with three conditions: walking, dance, stretching), we aimed to use baseline neuroimaging (resting state functional connectivity of two a priori defined seed regions), and baseline accelerometer measures of time spent sedentary to predict future pre-post changes in objectively measured time spent sedentary in daily life over the 6-month intervention. Our results demonstrated that functional connectivity between (1) the anterior cingulate cortex and the supplementary motor area and (2) the right anterior insula and the left temporoparietal/temporooccipital junction, predicted changes in time spent sedentary in the walking group. Functional connectivity of these brain regions did not predict changes in time spent sedentary in the dance nor stretch and tone conditions, but baseline time spent sedentary was predictive in these conditions. Our results add important knowledge toward understanding mechanistic associations underlying complex out-of-session sedentary behaviors within a walking intervention setting in older adults.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje