Influence of serum progesterone levels on the inflammatory response of female dogs with visceral leishmaniosis.

Autor: Bertolo PHL; School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil., Moutinho da Conceição MEBA; School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil., Emboaba da Costa RRM; School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil., Jacintho APP; School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil., Cipriano RS; Zoonosis Control Center, Araçatuba, São Paulo, Brazil., Moreira PRR; University Center of Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil. Electronic address: pamela_rreina@yahoo.com.br., Ferreira MA; School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil., Machado GF; School of Veterinary Medicine, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil., de Oliveira Vasconcelos R; School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Veterinary parasitology [Vet Parasitol] 2022 Feb; Vol. 302, pp. 109658. Date of Electronic Publication: 2022 Jan 13.
DOI: 10.1016/j.vetpar.2022.109658
Abstrakt: The aim of this study was to evaluate the histopathological changes to the mammary gland that occur in female dogs with visceral leishmaniosis and to correlate the findings with the parasite load, inflammatory cell profile in mammary tissue and serum progesterone levels. For this, 20 adult female dogs that were naturally infected with Leishmania infantum, not spayed, not pregnant and free from mammary tumors were used. They were divided into two groups: G1 (n = 9) with high serum progesterone levels and G2 (n = 11) with low serum progesterone levels. The parasite load and the immunophenotype of leukocytes infiltrated into the mammary tissue (CD3, CD4, CD8 and MCA874) were evaluated using the immunohistochemical technique. In the mammary gland, chronic inflammatory infiltrate was mainly found in G1, sometimes associated with granulomatous inflammation, higher parasite load and higher density of cells immunolabeled for CD3, CD4, CD8 and MCA874. A significant positive correlation (p < 0.05) was observed between the parasite load and the immunolabeled leukocytes. The influence of the serum progesterone level in the mammary gland of infected female dogs can contribute to the maintenance of an immunosuppressive cell profile and favor the persistence of the parasite in this site.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: