| Autor: |
García-Ramos M; Organic and Inorganic Chemistry Department, University of Oviedo, Avenida Julián Clavería 8, 33006 Oviedo, Spain. lavanderaivan@uniovi.es., Lavandera I; Organic and Inorganic Chemistry Department, University of Oviedo, Avenida Julián Clavería 8, 33006 Oviedo, Spain. lavanderaivan@uniovi.es. |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Feb 02; Vol. 20 (5), pp. 984-988. Date of Electronic Publication: 2022 Feb 02. |
| DOI: |
10.1039/d1ob02346b |
| Abstrakt: |
Transaminases have shown the ability to catalyze the amination of a series of aliphatic and (hetero)aromatic α,α-difluorinated ketones with high stereoselectivity, thus providing the corresponding β,β-difluoroamines in high isolated yields (55-82%) and excellent enantiomeric excess (>99%). It was also observed that these activated substrates could be quantitatively transformed by employing a small molar excess of the amine donor since this amination process was thermodynamically favored. Selected transformations could be scaled up to 500 mg, showing the robustness of this methodology. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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