The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.

Autor: Shelton JF; 23andMe Inc., Sunnyvale, CA, USA., Shastri AJ; 23andMe Inc., Sunnyvale, CA, USA., Fletez-Brant K; 23andMe Inc., Sunnyvale, CA, USA., Aslibekyan S; 23andMe Inc., Sunnyvale, CA, USA., Auton A; 23andMe Inc., Sunnyvale, CA, USA. aauton@23andme.com.
Jazyk: angličtina
Zdroj: Nature genetics [Nat Genet] 2022 Feb; Vol. 54 (2), pp. 121-124. Date of Electronic Publication: 2022 Jan 17.
DOI: 10.1038/s41588-021-00986-w
Abstrakt: Using online surveys, we collected data regarding COVID-19-related loss of smell or taste from 69,841 individuals. We performed a multi-ancestry genome-wide association study and identified a genome-wide significant locus in the vicinity of the UGT2A1 and UGT2A2 genes. Both genes are expressed in the olfactory epithelium and play a role in metabolizing odorants. These findings provide a genetic link to the biological mechanisms underlying COVID-19-related loss of smell or taste.
(© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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