Microenvironmental influences on T cell immunity in cancer and inflammation.

Autor: Heintzman DR; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37205, USA., Fisher EL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37205, USA., Rathmell JC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37205, USA. jeff.rathmell@vumc.org.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, 37205, USA. jeff.rathmell@vumc.org.
Jazyk: angličtina
Zdroj: Cellular & molecular immunology [Cell Mol Immunol] 2022 Mar; Vol. 19 (3), pp. 316-326. Date of Electronic Publication: 2022 Jan 17.
DOI: 10.1038/s41423-021-00833-2
Abstrakt: T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways. T cells must function in a wide variety of tissue settings, and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing importance. Both in inflamed and cancer tissues, a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape immunity. These include fever and increased temperatures, depletion of critical micro and macro-nutrients, and accumulation of inhibitory waste products. Here we review several of these factors and how the tissue microenvironment both shapes and constrains immunity.
(© 2022. The Author(s), under exclusive licence to CSI and USTC.)
Databáze: MEDLINE
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