Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.

Autor: Rotstein DS; US Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Rockville, MD, USA., Peloquin S; US Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Veterinary Laboratory Investigation and Response Network, Laurel, MD, USA., Proia K; US Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Veterinary Laboratory Investigation and Response Network, Laurel, MD, USA., Hart E; US Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Rockville, MD, USA., Lee J; Louisiana State University, Baton Rouge, LA, USA., Vyhnal KK; Louisiana State University, Baton Rouge, LA, USA., Sasaki E; Louisiana State University, Baton Rouge, LA, USA., Balamayooran G; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Asin J; University of California-Davis, San Bernardino, CA, USA., Southard T; Cornell University, Ithaca, NY, USA., Rothfeldt L; Arkansas Department of Health, Zoonotic Disease Section, Little Rock, AR, USA., Venkat H; Center for Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Arizona Department of Health Services, Phoenix, AZ, USA., Mundschenk P; Arizona Department of Agriculture, Phoenix, AZ, USA., McDermott D; New Jersey Department of Health, Communicable Disease Service, Trenton, NJ, USA., Crossley B; University of California-Davis, San Bernardino, CA, USA., Ferro P; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Gomez G; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Henderson EH; University of California-Davis, San Bernardino, CA, USA., Narayan P; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Paulsen DB; Louisiana State University, Baton Rouge, LA, USA., Rekant S; USDA APHIS Veterinary Services, Riverdale, MD, USA., Schroeder ME; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Tell RM; USDA National Veterinary Services Laboratories, Ames, IA, USA., Torchetti MK; USDA National Veterinary Services Laboratories, Ames, IA, USA., Uzal FA; University of California-Davis, San Bernardino, CA, USA., Carpenter A; Centers for Disease Control and Prevention, Atlanta, GA, USA., Ghai R; Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: Veterinary pathology [Vet Pathol] 2022 Jul; Vol. 59 (4), pp. 707-711. Date of Electronic Publication: 2022 Jan 18.
DOI: 10.1177/03009858211067467
Abstrakt: Documented natural infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exotic and companion animals following human exposures are uncommon. Those documented in animals are typically mild and self-limiting, and infected animals have only infrequently died or been euthanized. Through a coordinated One Health initiative, necropsies were conducted on 5 animals from different premises that were exposed to humans with laboratory-confirmed SARS-CoV-2 infection. The combination of epidemiologic evidence of exposure and confirmatory real-time reverse transcriptase-polymerase chain reaction testing confirmed infection in 3 cats and a tiger. A dog was a suspect case based on epidemiologic evidence of exposure but tested negative for SARS-CoV-2. Four animals had respiratory clinical signs that developed 2 to 12 days after exposure. The dog had bronchointerstitial pneumonia and the tiger had bronchopneumonia; both had syncytial-like cells with no detection of SARS-CoV-2. Individual findings in the 3 cats included metastatic mammary carcinoma, congenital renal disease, and myocardial disease. Based on the necropsy findings and a standardized algorithm, SARS-CoV-2 infection was not considered the cause of death in any of the cases. Continued surveillance and necropsy examination of animals with fatal outcomes will further our understanding of natural SARS-CoV-2 infection in animals and the potential role of the virus in development of lesions.
Databáze: MEDLINE