Circulating microRNAs fluctuations in exercise-induced cardiac remodeling: A systematic review.

Autor:	Sanchis-Gomar F; Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute Valencia, Spain., Arnau-Moyano M; Faculty of Sport Sciences, Universidad Europea de Madrid Madrid, Spain., Daimiel L; Nutritional Control of The Epigenome Group, Instituto Madrileño de Estudios Avanzados (IMDEA) Food, CEI UAM+CSIC Madrid 28049, Spain., Lippi G; Section of Clinical Biochemistry, University of Verona Verona, Italy., Leischik R; School of Medicine, Faculty of Health, Witten/Herdecke University Witten, Germany., Vallecillo N; Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid Madrid, Spain., Yvert T; Faculty of Sport Sciences, Universidad Europea de Madrid Madrid, Spain., Jiménez SL; Centre for Sport Studies, Rey Juan Carlos University Madrid, Spain., Santiago C; Faculty of Sport Sciences, Universidad Europea de Madrid Madrid, Spain., Pareja-Galeano H; Department of Physical Education, Sport and Human Movement, Universidad Autónoma de Madrid Madrid, Spain.
Jazyk:	angličtina
Zdroj:	American journal of translational research [Am J Transl Res] 2021 Dec 15; Vol. 13 (12), pp. 13298-13309. Date of Electronic Publication: 2021 Dec 15 (Print Publication: 2021).
Abstrakt:	MicroRNAs (miRNAs) are small non-coding RNAs that participate in gene expression regulation. It has been observed that circulating levels of miRNAs may fluctuate during exercise, showing numerous cardiac biological and physiological effects such as structural and functional adaptations. We aimed to provide an overview of the currently available information concerning the role of circulating miRNAs in cardiovascular adaptations in response to acute and/or chronic exercise training. Relevant studies published were searched in three databases: PubMed, Web of Science and Scopus. A combination of the following keywords was used: ("microRNA" OR "miRNA" OR "miR" AND "exercise" OR "training" OR "physical activity") AND "(heart hypertrophy" OR "cardiac remodeling" OR "cardiac muscle mass" OR "cardiac hypertrophy"). Only experimental studies, written in English and conducted in healthy individuals were included. Five articles met the inclusion criteria and were finally included in this systematic review after reviewing both title, abstract and full-text. A total of thirty-six circulating cardiac-related miRNAs were analyzed, but only five of them (miR-1, miR-133a, miR-146a, miR-206 and miR-221) were directly associated with cardiac adaptations parameters, while two of them (miR-1 and miR-133a) were related to cardiac hypertrophy. Most of them were upregulated immediately after a marathon and returned to basal levels at longer times. Therefore, we conclude that, although evidence is still limited, and long-term studies are needed to obtain more robust evidence, exercise is more likely to affect circulating cardiac-related miRNAs levels. Competing Interests: None. (AJTR Copyright © 2021.)
Databáze:	MEDLINE
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