Occurrence and Risk Factors of Uveitis in Juvenile Psoriatic Arthritis: Data From a Population-based Nationwide Study in Germany.

Autor:	Baquet-Walscheid K; K. Baquet-Walscheid, MD, A. Heiligenhaus, MD, Department of Ophthalmology at St. Franziskus Hospital, Muenster, and University of Duisburg-Essen, Faculty of Medicine, Essen; karoline.walscheid@uveitis-zentrum.de., Rothaus K; K. Rothaus, MSc, Department of Ophthalmology at St. Franziskus Hospital, Muenster., Niewerth M; M. Niewerth, MSc, German Rheumatism Research Center, a Leibniz Institute, Berlin., Klotsche J; J. Klotsche, PhD, German Rheumatism Research Center, a Leibniz Institute, and Charité - University Medicine Berlin, Institute for Social Medicine, Epidemiology and Health Economics, Berlin., Minden K; K. Minden, MD, German Rheumatism Research Center, a Leibniz Institute, and Charité - University Medicine Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany., Heiligenhaus A; K. Baquet-Walscheid, MD, A. Heiligenhaus, MD, Department of Ophthalmology at St. Franziskus Hospital, Muenster, and University of Duisburg-Essen, Faculty of Medicine, Essen.
Jazyk:	angličtina
Zdroj:	The Journal of rheumatology [J Rheumatol] 2022 Jul; Vol. 49 (7), pp. 719-724. Date of Electronic Publication: 2022 Jan 15.
DOI:	10.3899/jrheum.210755
Abstrakt:	Objective: Data on uveitis in juvenile psoriatic arthritis (JPsA), a category of juvenile idiopathic arthritis (JIA), are scarce. We describe prevalence and risk factors for JPsA-associated uveitis (JPsA-U). Methods: Cross-sectional data from the German National Pediatric Rheumatological Database (2002-2014) were used to characterize JPsA-U and assess risk factors for the development of uveitis. Results: Uveitis developed in 6.6% of 1862 patients with JPsA. Patients with JPsA-U were more frequently female (73.0 vs 62.9%, P = 0.03), antinuclear antibody (ANA) positive (60.3 vs 37.0%, P < 0.001), younger at JPsA onset (5.3 ± 4.1 vs 9.3 ± 4.4 yrs, P < 0.001), and treated with disease-modifying antirheumatic drugs (DMARDs) significantly more frequently compared with JPsA patients without uveitis. On a multivariable analysis of a subgroup of 655 patients enrolled in the study ≤ 1 year after arthritis onset, mean clinical Juvenile Arthritis Disease Activity Score for 10 joints during study documentation was significantly associated with uveitis development. Children with early onset of JPsA (aged < 5 yrs vs ≥ 5 yrs) were significantly more frequently ANA positive (48.4% vs 35.7%, P < 0.001), affected by uveitis (17.3% vs 3.8%, P < 0.001), and treated with DMARDs (52.9% vs 43.8%, P < 0.001), but less often affected by skin disease (55.3% vs 61.0%, P = 0.03). Conclusion: The characteristics of patients with JPsA developing uveitis are similar to those of patients with uveitis in other JIA categories, such as oligoarticular JIA. Children with early-onset JPsA are at a higher risk for ocular involvement. Our data support the notion of a major clinical difference between those patients with early vs late onset of JPsA. (Copyright © 2022 by the Journal of Rheumatology.)
Databáze:	MEDLINE
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