Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa.

Autor: Bondaryuk AN; Limnological Institute SB RAS, Ulan-Batorskaya 3, 664033 Irkutsk, Russia; Irkutsk Antiplague Research Institute of Siberia and the Far East, Trilisser 78, 664047 Irkutsk, Russia. Electronic address: bondaryuk@chumin.irkutsk.ru., Andaev EI; Irkutsk Antiplague Research Institute of Siberia and the Far East, Trilisser 78, 664047 Irkutsk, Russia., Dzhioev YP; Irkutsk State Medical University, Irkutsk, Russia., Zlobin VI; Irkutsk State Medical University, Irkutsk, Russia., Tkachev SE; Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; Institute of Fundamental Medicine and Biology, Kazan State University, Kazan, Russia., Kozlova IV; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev 16, 664003 Irkutsk, Russia., Bukin YS; Limnological Institute SB RAS, Ulan-Batorskaya 3, 664033 Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2022 Apr; Vol. 169, pp. 107411. Date of Electronic Publication: 2022 Jan 12.
DOI: 10.1016/j.ympev.2022.107411
Abstrakt: The tick-borne flavivirus (TBFV) group contains at least 12 members where five of them are important pathogens of humans inducing diseases with varying severity (from mild fever forms to acute encephalitis). The taxonomy structure of TBFV is not fully clarified at present. In particular, there is a number of paraphyletic issues of tick-borne encephalitis virus (TBEV) and louping-ill virus (LIV). In this study, we aimed to apply different bioinformatic approaches to analyze all available complete genome amino acid sequences to delineate TBFV members at the species level. Results showed that the European subtype of TBEV (TBEV-E) is a distinct species unit. LIV, in turn, should be separated into two species. Additional analysis of TBEV and LIV antigenic determinant diversity also demonstrate that TBEV-E and LIV are significantly different both from each other and from the other TBEV subtypes. The analysis of available literature provided data on other virus phenotypic particularities that supported our hypothesis. So, within the TBEV + LIV paraphyletic group, we offer to assign four species to get a more accurate understanding of the TBFV interspecies structure according to the modern monophyletic conception.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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