Microglia are involved in the protection of memories formed during sleep deprivation.

Autor:	Gentry NW; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA., McMahon T; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA., Yamazaki M; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA., Webb J; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA., Arnold TD; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA.; Department of Physical Rehabilitation Science, University of California, San Francisco, San Francisco, CA, 94143, USA.; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA., Rosi S; Department of Physical Rehabilitation Science, University of California, San Francisco, San Francisco, CA, 94143, USA.; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.; Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, 94143, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, 94143, USA., Ptáček LJ; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA.; Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, 94143, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, 94143, USA., Fu YH; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA.; Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, 94143, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, 94143, USA.
Jazyk:	angličtina
Zdroj:	Neurobiology of sleep and circadian rhythms [Neurobiol Sleep Circadian Rhythms] 2021 Dec 28; Vol. 12, pp. 100073. Date of Electronic Publication: 2021 Dec 28 (Print Publication: 2022).
DOI:	10.1016/j.nbscr.2021.100073
Abstrakt:	Sleep deprivation can generate inflammatory responses in the central nervous system. In turn, this inflammation increases sleep drive, leading to a rebound in sleep duration. Microglia, the innate immune cells found exclusively in the CNS, have previously been found to release inflammatory signals and exhibit altered characteristics in response to sleep deprivation. Together, this suggests that microglia may be partially responsible for the brain's response to sleep deprivation through their inflammatory activity. In this study, we ablated microglia from the mouse brain and assessed resulting sleep, circadian, and sleep deprivation phenotypes. We find that microglia are dispensable for both homeostatic sleep and circadian function and the sleep rebound response to sleep deprivation. However, we uncover a phenomenon by which microglia appear to be essential for the protection of fear-conditioning memories formed during the recovery sleep period following a period of sleep deprivation. This phenomenon occurs potentially through the upregulation of synaptic-homeostasis related genes to protect nascent dendritic spines that may be otherwise removed or downscaled during recovery sleep. These findings further expand the list of known functions for microglia in synaptic modulation. Competing Interests: The authors declare no competing interests for this study. (© 2021 Published by Elsevier Inc.)
Databáze:	MEDLINE
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