Kuntai Capsule Combined With Letrozole on Gonadal Hormone Levels and Ovarian Function in Patients With PCOS: A Systematic Review and Meta-Analysis.

Autor:	Tang X; Sichuan Integrative Medicine Hospital, Chengdu, China.; Sichuan Institute for Translational Chinese Medicine, Chengdu, China.; Sub-Health Clinical Detection and Evaluation Laboratory, Chengdu, China., Huang Q; Chengdu University of Traditional Chinese Medicine (TCM), Chengdu, China., Wang C; Sichuan Integrative Medicine Hospital, Chengdu, China.; Sub-Health Clinical Detection and Evaluation Laboratory, Chengdu, China.; Chengdu Medical College, Chengdu, China., Zhang D; Sichuan Integrative Medicine Hospital, Chengdu, China.; Sub-Health Clinical Detection and Evaluation Laboratory, Chengdu, China., Dong S; Respiratory Department, Chengdu First People's Hospital, Chengdu, China.; The University of British Columbia (UBC) Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada., Yu C; Sichuan Integrative Medicine Hospital, Chengdu, China.; Sub-Health Clinical Detection and Evaluation Laboratory, Chengdu, China.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Dec 28; Vol. 12, pp. 789909. Date of Electronic Publication: 2021 Dec 28 (Print Publication: 2021).
DOI:	10.3389/fendo.2021.789909
Abstrakt:	Background: The efficacy of Kuntai capsule combined with letrozole (LE) in improving ovarian function of polycystic ovary syndrome (PCOS) has been evaluated before, but there is still a lack of evidence-based support for the regulation of sex hormone levels. In recent years, new randomized clinical trials (RCTs) have been reported on the effect of combined therapy on regulating sex hormone levels. Objective: We aimed to systematically evaluate the efficacy of Kuntai capsule combined with LE in the treatment of PCOS. Methods: A search across the China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang database, PubMed, Web of Science, The Cochrane Library, and Embase was conducted on Kuntai capsule combined with LE in the treatment of PCOS. The time of the self-built database was up to April 30, 2021. RCTs of LE in the control group and LE combined with Kuntai capsule in the experimental group were selected. RevMan5.3 software was used for data analysis. Results: A total of 17 studies were gathered, which included 1,684 patients. The meta-analysis results showed that the total effective rate of the combined group was 93.36% and that of the LE group was 78.15%. The improvement in the ovulation rate, pregnancy rate, number of mature follicles, endometrial thickness, cervical mucus score, and serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) in the combined group was consistent with the results of a previous meta-analysis and was better than that in the LE group ( p < 0.05). In addition, the combination group was better than the LE group in regulating the levels of estradiol (E2) and testosterone (T) ( p < 0.05). There were no adverse drug reactions in the two groups during treatment. Conclusion: As a type of pure traditional Chinese medicine preparation, Kuntai capsule combined with LE had a better effect than LE alone in the treatment of PCOS, with advantages mainly reflected in enhancing ovarian function and regulating the levels of sex hormones in vivo , among others, but the value of combined therapy still needs to be verified by more high-quality RCTs. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Tang, Huang, Wang, Zhang, Dong and Yu.)
Databáze:	MEDLINE
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