SynCoPa: Visualizing Connectivity Paths and Synapses Over Detailed Morphologies.

Autor:	Galindo SE; Ciencias de la Computación, Arquitectura de Computado, Lenguajes y Sistemas Informáticos y Estadística e Investigación Operativa, Esc. Tec. Sup. de Ingeniería Informática, Rey Juan Carlos University, Madrid, Spain., Toharia P; DATSI, ETSIINF, Universidad Politécnica de Madrid, Madrid, Spain.; Center for Computational Simulation, Universidad Politécnica de Madrid, Madrid, Spain., Robles OD; Ciencias de la Computación, Arquitectura de Computado, Lenguajes y Sistemas Informáticos y Estadística e Investigación Operativa, Esc. Tec. Sup. de Ingeniería Informática, Rey Juan Carlos University, Madrid, Spain.; Center for Computational Simulation, Universidad Politécnica de Madrid, Madrid, Spain., Pastor L; Ciencias de la Computación, Arquitectura de Computado, Lenguajes y Sistemas Informáticos y Estadística e Investigación Operativa, Esc. Tec. Sup. de Ingeniería Informática, Rey Juan Carlos University, Madrid, Spain.; Center for Computational Simulation, Universidad Politécnica de Madrid, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroinformatics [Front Neuroinform] 2021 Dec 27; Vol. 15, pp. 753997. Date of Electronic Publication: 2021 Dec 27 (Print Publication: 2021).
DOI:	10.3389/fninf.2021.753997
Abstrakt:	Brain complexity has traditionally fomented the division of neuroscience into somehow separated compartments; the coexistence of the anatomical, physiological, and connectomics points of view is just a paradigmatic example of this situation. However, there are times when it is important to combine some of these standpoints for getting a global picture, like for fully analyzing the morphological and topological features of a specific neuronal circuit. Within this framework, this article presents SynCoPa, a tool designed for bridging gaps among representations by providing techniques that allow combining detailed morphological neuron representations with the visualization of neuron interconnections at the synapse level. SynCoPa has been conceived for the interactive exploration and analysis of the connectivity elements and paths of simple to medium complexity neuronal circuits at the connectome level. This has been done by providing visual metaphors for synapses and interconnection paths, in combination with the representation of detailed neuron morphologies. SynCoPa could be helpful, for example, for establishing or confirming a hypothesis about the spatial distributions of synapses, or for answering questions about the way neurons establish connections or the relationships between connectivity and morphological features. Last, SynCoPa is easily extendable to include functional data provided, for example, by any of the morphologically-detailed simulators available nowadays, such as Neuron and Arbor, for providing a deep insight into the circuits features prior to simulating it, in particular any analysis where it is important to combine morphology, network topology, and physiology. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Galindo, Toharia, Robles and Pastor.)
Databáze:	MEDLINE
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