Role of the SARS-CoV-2 virus in the appearance of new onset type 1 diabetes mellitus in children in Gran Canaria, Spain.

Autor:	Nóvoa-Medina Y; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain.; Asociación Canaria para la Investigación Pediátrica (ACIP canarias), Canary Islands, Spain.; Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria (ULPGC), Canary Islands, Spain., Pavlovic-Nesic S; Pediatric Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., González-Martín JM; Research Unit, University Hospital Dr. Negrín, Las Palmas de GC, Canary Islands, Spain., Hernández-Betancor A; Microbiology Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., López S; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., Domínguez-García A; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., Quinteiro-Domínguez S; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., Cabrera M; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., De La Cuesta A; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., Caballero-Fernández E; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., González-Perera MA; Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., De Miguel-Martínez I; Microbiology Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain., Ogle GD; Life for a Child Program, Diabetes NSW & ACT, Sydney, Australia., Wägner AM; Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria (ULPGC), Canary Islands, Spain.; Endocrinology Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC, Canary Islands, Spain.
Jazyk:	angličtina
Zdroj:	Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2022 Jan 17; Vol. 35 (3), pp. 393-397. Date of Electronic Publication: 2022 Jan 17 (Print Publication: 2022).
DOI:	10.1515/jpem-2021-0727
Abstrakt:	Objectives: It has been hypothesized that SARS-CoV-2 may play a role in the development of different forms of diabetes mellitus (DM). The Canary Islands have the highest incidence of type 1 DM (T1DM) reported in Spain (30-35/100,000 children under 14 years/year). In 2020-2021 we observed the highest incidence so far on the island of Gran Canaria, as a result of which we decided to evaluate the possible role of COVID-19 in the increased number of onsets. Methods: We examined the presence of IgG antibodies against SARS-CoV-2 in children with new onset T1DM between October 2020 and August 2021. We compared recent T1DM incidence with that of the previous 10 years. Results: Forty-two patients were diagnosed with T1DM (48.1/100,000 patients/year), representing a nonsignificant 25.7% increase from the expected incidence. Of the 33 patients who consented to the study, 32 presented negative IgG values, with only one patient reflecting undiagnosed past infection. Forty-four percent of patients presented with ketoacidosis at onset, which was similar to previous years. Conclusions: We conclude that there is no direct relationship between the increased incidence of T1DM and SARS-CoV-2 in the region. The COVID-19 pandemic did not result in an increased severity of T1DM presentation. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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