Superhydrophobic Surfaces as a Source of Airborne Singlet Oxygen through Free Space for Photodynamic Therapy.

Autor: Aebisher D; Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland., Bartusik-Aebisher D; Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland., Belh SJ; Department of Chemistry, Brooklyn College, City University of New York, Brooklyn, New York 10314, United States.; Ph.D. Program in Chemistry, Graduate Center of City University of New York, New York, New York 10016, United States., Ghosh G; Department of Chemistry, Brooklyn College, City University of New York, Brooklyn, New York 10314, United States.; Ph.D. Program in Chemistry, Graduate Center of City University of New York, New York, New York 10016, United States., Durantini AM; Department of Chemistry, Brooklyn College, City University of New York, Brooklyn, New York 10314, United States.; IDAS-CONICET, Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, Córdoba X5804BYA, Argentina., Liu Y; Ph.D. Program in Chemistry, Graduate Center of City University of New York, New York, New York 10016, United States.; Department of Chemistry, College of Staten Island, City University of New York, Staten Island, New York 10314, United States., Xu Q; Department of Chemistry, College of Staten Island, City University of New York, Staten Island, New York 10314, United States., Lyons AM; Ph.D. Program in Chemistry, Graduate Center of City University of New York, New York, New York 10016, United States.; Department of Chemistry, College of Staten Island, City University of New York, Staten Island, New York 10314, United States., Greer A; Department of Chemistry, Brooklyn College, City University of New York, Brooklyn, New York 10314, United States.; Ph.D. Program in Chemistry, Graduate Center of City University of New York, New York, New York 10016, United States.
Jazyk: angličtina
Zdroj: ACS applied bio materials [ACS Appl Bio Mater] 2020 Apr 20; Vol. 3 (4), pp. 2370-2377. Date of Electronic Publication: 2020 Mar 31.
DOI: 10.1021/acsabm.0c00114
Abstrakt: A superhydrophobic (SH) sandwich system has been developed to enable "contact-free" airborne singlet oxygen ( 1 O 2 ) delivery to a water droplet. The contact-free feature means that the sensitizer is physically separated from the droplet, which presents opportunities for photodynamic therapy (PDT). Trapping of airborne 1 O 2 in a H 2 O droplet residing on a lower SH surface was monitored with 9,10-anthracene dipropionate dianion by varying distances to an upper 1 O 2 -generating surface. Short distances of 20 μm efficiently delivered airborne 1 O 2 to the droplet in single-digit picomolar steady-state concentrations. Delivery decreases linearly with distance, but 50% of the 1 O 2 steady-state concentration is trapped at a distance of 300 μm from the generating surface. The 1270 nm luminescence intensity was measured within the SH sandwich system, confirming the presence of airborne 1 O 2 . Physical quenching of 1 O 2 to ground-state 3 O 2 by the water droplet itself and both physical and chemical quenching of 1 O 2 by the water droplet containing the trap 9,10-anthracene dipropionate dianion are observed. Unlike a majority of work in the field of PDT with dissolved sensitizers, where 1 O 2 diffuses short (hundreds of nanometers) distances, we show the delivery of airborne 1 O 2 via a superhydrophobic surface is effective through air in tenths of millimeters distances to oxidize an organic compound in water. Our results provide not only potential relevance to PDT but also surface bacterial inactivation processes.
Databáze: MEDLINE
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