Executive functioning and serum lipid fractions in Parkinson's disease-a possible sex-effect: the PACOS study.

Autor: Luca A; Department of Surgical and Medical Sciences Advanced Technologies 'G.F. Ingrassia', University of Catania, Via Santa Sofia 78, 95123, Catania, Italy., Monastero R; Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy. roberto.monastero@unipa.it., Cicero CE; Department of Surgical and Medical Sciences Advanced Technologies 'G.F. Ingrassia', University of Catania, Via Santa Sofia 78, 95123, Catania, Italy., Baschi R; Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy., Donzuso G; Department of Surgical and Medical Sciences Advanced Technologies 'G.F. Ingrassia', University of Catania, Via Santa Sofia 78, 95123, Catania, Italy., Mostile G; Department of Surgical and Medical Sciences Advanced Technologies 'G.F. Ingrassia', University of Catania, Via Santa Sofia 78, 95123, Catania, Italy., Restivo V; Department of Sciences for Health Promotion and Mother-Child Care, University of Palermo, Palermo, Italy., Di Giorgi L; Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy., Caccamo M; Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy., Zappia M; Department of Surgical and Medical Sciences Advanced Technologies 'G.F. Ingrassia', University of Catania, Via Santa Sofia 78, 95123, Catania, Italy., Nicoletti A; Department of Surgical and Medical Sciences Advanced Technologies 'G.F. Ingrassia', University of Catania, Via Santa Sofia 78, 95123, Catania, Italy. anicolet@unict.it.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2022 Mar; Vol. 129 (3), pp. 287-293. Date of Electronic Publication: 2022 Jan 13.
DOI: 10.1007/s00702-022-02460-1
Abstrakt: The association between dyslipidemia and cognitive performance in Parkinson's disease (PD) patients still needs to be clarified. Aim of the study was to evaluate the presence of possible associations between serum lipids fractions and executive dysfunction also exploring the sex-specific contribute of lipids level on cognition. Patients from the PACOS cohort, who underwent a complete serum lipid profile measures (total cholesterol-TC, low-density lipoprotein cholesterol-LDL, high-density lipoprotein cholesterol-HDL and triglycerides-TG) were selected. Adult Treatment Panel III guidelines of the National Cholesterol Education Program were used to classify normal/abnormal lipid fractions. Executive functioning was assessed with the Frontal Assessment Battery (FAB). Logistic regression was performed to assess associations between lipids fractions and FAB score. Correlations between lipids fractions and FAB score were explored. Sex-stratified analysis was performed. Three hundred and forty-eight PD patients (148 women; age 66.5 ± 9.5 years; disease duration 3.9 ± 4.9 years) were enrolled. Women presented significantly higher TC, LDL and HDL than men. In the whole sample, any association between lipid profile measures and FAB score was found. Among women, a positive association between hypertriglyceridemia and FAB score under cutoff was found (OR 3.4; 95%CI 1.29-9.03; p value 0.013). A statistically significant negative correlation was found between the FAB score and triglyceride serum levels (r = - 0.226; p value 0.005). Differently, among men, a statistically significant negative association between hypercholesterolemia and FAB score under cutoff (OR 0.4; 95%CI 0.17-0.84; p value 0.018) and between high LDL levels and FAB score under cutoff (OR 0.4; 95%CI 0.18-0.90; p value 0.027) were found. Our data suggest a sex-specific different role of lipids in executive functioning.
(© 2022. The Author(s).)
Databáze: MEDLINE
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