Intergenerational protein deficiency and adolescent reproductive function of subsequent female generations (F 1 and F 2 ) in rat model.
Autor: | Abey NO; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria., Ebuehi OAT; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria., Imaga NOA; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria. |
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Jazyk: | angličtina |
Zdroj: | Current research in physiology [Curr Res Physiol] 2021 Dec 22; Vol. 5, pp. 16-24. Date of Electronic Publication: 2021 Dec 22 (Print Publication: 2022). |
DOI: | 10.1016/j.crphys.2021.12.003 |
Abstrakt: | Background: Efficient reproductive function is an important characteristic that has evolved through natural selection. Nutrition can modulate reproductive activities at different levels, and its effect on reproduction is deemed complex and less predictable. Objective: This study aims at investigating the underlying effect of persistent dietary protein deficiency during early life on reproductive parameters of subsequent (F Method: Rats in group of four (4) were fed daily, different ration of protein diet (PD) formulated as: 21% protein diet, 10%protein diet, 5%protein diet and control diet (rat chow, containing 16-18% protein). They were fed ad libitum before mating, throughout gestation and lactation, and next generations were weaned to the maternal diet. Reproductive function analysis (which include; gestation and pubertal hormonal profiling, onset of puberty, oestrus cyclicity, sexual response) and morphometric analysis of the ovarian structure were carried out to assess associated consequences. Results: There was significant reduction in the fertility index (Control; 85.8%., 21%PD; 88.43%., as compared to 10%PD; 65.9%., 5%PD; 35.78%.,) at F Conclusion: Reproductive status of a female organism depends on the maintenance of ovarian structure and function that has been associated with the hypothalamic pituitary-gonadal axis, hormonal events and sexual maturity. There is therefore an association between persistent early life protein deficiency and reproductive response which mechanistically involves life-long changes in key ovarian cytoarchitecture and function. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors.) |
Databáze: | MEDLINE |
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