Pneumococcal serotypes causing non-invasive pneumonia in adults from a South Indian tertiary care hospital and the impact of the newer conjugate vaccines.

Autor:	Varghese R; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Yesudhason BL; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Vimala LR; Department of Radiology, Christian Medical College, Vellore, India., Neeravi A; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Anandhan K; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Baskar P; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Elangovan D; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Manesh A; Department of Infectious Diseases, Christian Medical College, Vellore, India., James P; Department of Respiratory Medicine, Christian Medical College, Vellore, India., Gupta R; Department of Respiratory Medicine, Christian Medical College, Vellore, India., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore, India.
Jazyk:	angličtina
Zdroj:	Access microbiology [Access Microbiol] 2021 Dec 07; Vol. 3 (12), pp. 000258. Date of Electronic Publication: 2021 Dec 07 (Print Publication: 2021).
DOI:	10.1099/acmi.0.000258
Abstrakt:	Background: Streptococcus pneumoniae is the leading cause of community-acquired pneumonia (CAP) in adults. Ageing, chronic conditions and comorbidities are important risk factors for pneumococcal pneumonia. Purpose: There is lack of data on the pneumococcal serotypes causing non-invasive pneumonia in India. This study aims to determine the prevalent pneumococcal serotypes causing non-invasive pneumonia, the associated comorbidities, and the coverage of both the available pneumococcal vaccines in India and conjugate vaccines that are currently undergoing clinical trials. Methods: A total of 280 subjects (aged >16 years) who had clinical symptoms correlating with radiological findings for non-invasive bacteremic pneumonia and microbiological evidence of S. pneumoniae between 2018 and 2020 were included. The clinical, demographic, radiological and microbiological findings were retrieved from the Hospital Information System (HIS). Result: The common serotypes in order of prevalence were 19F, 9V, 23F, 6B, 11A, 13, 34, 10A, 19A and 6A. The predominant non-vaccine serotypes were 13, 34, 35B, 31 and 16F. The associated radiological findings were pneumonic consolidation and multi-lobar involvement. Other coinfected bacterial pathogens included H. influenzae, S. aureus , K. pneumoniae and P. aeruginosa . Conclusion: The pneumococcal vaccines: PCV10/GSK, PCV10/SII, PCV13, PCV15, PCV20 and PPSV23 provide an overall serotype coverage of 36, 41, 47, 48, 61 and 69 %, respectively of S. pneumoniae causing non-invasive pneumonia in South India. Increasing catch-up vaccination using PCV10(SII) in pre-school children could have a more significant impact on reducing pneumococcal pneumonia in adults (>50 years) in terms of increased herd immunity at an affordable cost. Competing Interests: The authors declare that there are no conflicts of interest. (© 2021 The Authors.)
Databáze:	MEDLINE
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