CNS Histoplasmosis as a Gliosarcoma mimicker: The diagnostic dilemma of solitary brain lesions.

Autor:	Khalaf SA; University of Missouri, Division of Infectious Diseases, Columbia, MO, USA., Patel P; University of Missouri, Division of Infectious Diseases, Columbia, MO, USA., Caruso CR; University of Missouri, Department of Pathology and Anatomical Sciences, Columbia, MO, USA., Parrett T; University of Missouri, Department of Pathology and Anatomical Sciences, Columbia, MO, USA., Bran A; University of Missouri, Division of Infectious Diseases, Columbia, MO, USA.
Jazyk:	angličtina
Zdroj:	IDCases [IDCases] 2021 Dec 16; Vol. 27, pp. e01364. Date of Electronic Publication: 2021 Dec 16 (Print Publication: 2022).
DOI:	10.1016/j.idcr.2021.e01364
Abstrakt:	Histoplasmosis is usually a benign, self-limited disease with lungs predilection. However, it might manifest as a disseminated disease in immunocompromised individuals. The involvement of the central nervous system (CNS) accounts for about 5-10% of cases with disseminated disease. Isolated histoplasmosis of the CNS is rare, and the literature shows only a few reported cases. By imaging studies, it usually presents as an isolated ring-enhancing lesion. Its spectrum of symptoms ranges from acute severe infection to progressive chronic meningitis, which delays the initial diagnosis, correct work-up and initiation of appropriate therapy. We present a case of a 57-year-old man from the Midwest of the United States who misdiagnosed with Gliosarcoma in 2019, for which he underwent appropriate management for Gliosarcoma. Presented for follow-up after new neurological symptoms; worsening in ring-enhancing brain lesions was found on magnetic resonance image MRI. After a re-examination of surgical pathological cases, histoplasmosis of the CNS was diagnosed. Failure of diagnosis CNS histoplasmosis early can lead to poor outcome and decrease chances of recovery. (© 2021 The Authors.)
Databáze:	MEDLINE
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