A case for a national registry of red blood cell antibodies.

Autor: Mathur G; Department of Pathology, Saint Luke's Health System, Kansas City, Missouri, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.; Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Wilkinson MB; Department of Pathology, Saint Luke's Health System, Kansas City, Missouri, USA., Island ER; Department of Pathology, Saint Luke's Health System, Kansas City, Missouri, USA., Menitove JE; JEM Consulting, Kansas City, Missouri, USA., Tilzer L; Department of Pathology, Saint Luke's Health System, Kansas City, Missouri, USA.
Jazyk: angličtina
Zdroj: Vox sanguinis [Vox Sang] 2022 May; Vol. 117 (5), pp. 738-740. Date of Electronic Publication: 2022 Jan 12.
DOI: 10.1111/vox.13250
Abstrakt: Background and Objectives: Red blood cell (RBC) antibody levels diminish over time and negative antibody screen are commonly seen in patients with a history of antibodies. Most hospitals do not have access to a shared registry of antibodies previously detected at other hospitals.
Materials and Methods: We describe a case where the patient was found to be at high risk of bleeding during liver transplantation. Antibody screen on admission was negative but a history of anti-Jk a was identified on reviewing patient's history in local registry of RBC antibodies. The surgery was pushed back to arrange for antigen-negative units. The patient received a total of 16 Jk(a-) RBC units during the admission.
Results: No acute or delayed transfusion adverse reactions were seen. However, if the history of anti-Jk a identified at another local hospital was not known, approximately three-quarters of the units transfused would have been Jk(a+). Transfusing Jk(a+) units could have potentially exposed the patient to risk of developing an acute and/or delayed haemolytic transfusion reaction which could have led to significant morbidity and perhaps mortality.
Conclusion: With this case report, we build a case for developing a national registry of RBC antibodies to help improve patient safety and outcomes.
(© 2022 International Society of Blood Transfusion.)
Databáze: MEDLINE
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