| Autor: |
Alsharif NA; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Aleisa FA; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Liu G; Division of Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Ooi BS; Division of Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Patel N; Division of Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Ravasi T; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Merzaban JS; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia., Kosel J; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia.; Division of Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Saudi Arabia. |
| Abstrakt: |
Conventional chemotherapy and radiation therapy are often insufficient in eliminating cancer and are accompanied by severe side effects, due to a lack in the specificity of their targeting. Magnetic iron nanowires have made a great contribution to the nanomedicine field because of their low toxicity and ease of manipulation with the magnetic field. Recently, they have been used in magnetic resonance imaging and wireless magnetomechanical and photothermal treatments. The addition of active targeting moieties to these nanowires thus creates a multifunctional tool that can boost therapeutic efficacies through the combination of different treatments toward a specific target. Colon cancer is the third most commonly occurring cancer, and 90 ± 2.5% of colon cancer cells express the glycoprotein CD44. Iron nanowires with an iron oxide surface are biocompatible, multifunctional materials that can be controlled by magnetic fields and heated by laser irradiation. Here, they were functionalized with anti-CD44 antibodies and used in a combination therapy that included magnetomechanical and photothermal treatments on colon cancer cells. The functionalization resulted in a 3-fold increase of nanowire internalization in colon cancer cells compared to control cells and did not affect the antigenicity and magnetic properties. It also increased the efficacy of killing from 35 ± 1% to more than 71 ± 2%, showing that the combination therapy was more effective than individual therapies alone. |
