Incidence of Glaucoma Progression and Rate of Visual Field Deterioration in a Cohort of Urban Ghanaians.

Autor:	Mwanza JC; Department of Ophthalmology, University of North Carolina at Chapel Hill., Tulenko SE; Department of Ophthalmology, University of North Carolina at Chapel Hill., Budenz DL; Department of Ophthalmology, University of North Carolina at Chapel Hill., Herndon LW; Department of Ophthalmology, Duke University, Durham, NC., Hall A; Department of Ophthalmology, The Glaucoma Center, Bowie, MD., Hay-Smith G; The Moreton Eye Group, Brisbane, Qld, Australia., Kim HY; Department of Ophthalmology, Kaiser Permanente Woodland Hills Medical Center, Woodland Hills, CA., Mathenge E; Department of Ophthalmology, Duke University, Durham, NC., Spratt A; South Florida Eye Health, Hollywood, FL., Tanna AP; Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL., Barton K; Moorfields Eye Hospital NHS Trust Institute of Ophthalmology, University College of London, London, UK.
Jazyk:	angličtina
Zdroj:	Journal of glaucoma [J Glaucoma] 2022 Jul 01; Vol. 31 (7), pp. 503-510. Date of Electronic Publication: 2022 Jan 12.
DOI:	10.1097/IJG.0000000000001984
Abstrakt:	Prcis: The annual incidence of glaucoma progression (9.7%) and rates of visual field mean deviation (MD) change in progressors (-1.02±0.06 dB/y) are high in a small cohort of urban Ghanaians. Purpose: To report the incidence of glaucoma progression and the rate of visual field deterioration in a small cohort of Ghanaians. Methods: One hundred ten subjects (204 eyes) diagnosed with glaucoma at a baseline population-based screening examination were re-examined a mean of 8.3±0.8 years later. Eyes were classified as having progressed if the optic disc alone, visual field alone or both showed significant glaucomatous changes on follow-up. Visual field MD was used to calculate the rate of visual field progression. Results: Progression was observed in 89 (80.9%, 9.7%/year) subjects (130 eyes). Progression occurred in 32 (31.7%, 3.8%/year) subjects by optic disc alone (46 eyes), 38 (44.7%, 5.4%/year) subjects by visual field alone (58 eyes), and 19 (25.0%, 3.0%/year) subjects by both modalities (26 eyes). The average rate of change in MD differed significantly between progressors (-1.02±1.06 dB/y) and nonprogressors (+0.089±0.49 dB/y), P =0.001. The rate of visual field worsening was greater among those who were classified as having progressed by both structure and function (-1.29±0.68 dB/y) and by function alone (-1.21±1.20 dB/y) than by structure alone (-0.55±0.76 dB/y). Progression was significantly associated with older age [odds ratio (OR), 1.42; P <0.001] and higher baseline intraocular pressure (OR, 1.18; P =0.002). Factors associated with rate of MD change were baseline older age (OR, 1.66; P =0.003), higher intraocular pressure (OR, 2.81; P =0.007), better visual field MD (OR, 1.41; P =0.004), and systemic hypertension (OR, 1.15; P =0.029). Conclusion: The incidence and rate of visual field progression are high in this longitudinal study of Ghanaian subjects with glaucoma. The findings may have important clinical and public health policy ramifications. Competing Interests: Disclosure: The authors declare no conflict of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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