Klebsiella-induced infections in domestic species: a case-series study in 697 animals (1997-2019).

Autor: Ribeiro MG; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil. marcio.ribeiro@unesp.br.; School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu, SP, 18618-681, Brazil. marcio.ribeiro@unesp.br., de Morais ABC; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Alves AC; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Bolaños CAD; Department of Veterinary Medicine, Faculty of Veterinary Medicine and Animal Sciences, Antonio Nariño University, Bogota, Colombia., de Paula CL; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Portilho FVR; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., de Nardi Júnior G; Technology Faculty, FATEC, Botucatu, SP, Brazil., Lara GHB; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., de Souza Araújo Martins L; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Moraes LS; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Risseti RM; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Guerra ST; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Bello TS; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Siqueira AK; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Bertolini AB; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Rodrigues CA; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Paschoal NR; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., de Almeida BO; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Listoni FJP; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Sánchez LFG; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil., Paes AC; Department of Animal Production and Preventive Veterinary Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil.
Jazyk: angličtina
Zdroj: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2022 Mar; Vol. 53 (1), pp. 455-464. Date of Electronic Publication: 2022 Jan 11.
DOI: 10.1007/s42770-021-00667-0
Abstrakt: Klebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997-2019). The isolates were obtained from different clinical disorders from dogs (n = 393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n = 22), sheep (n = 5), goats (n = 2), and buffalo (n = 1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 = 12.2%), reproductive (85/697 = 12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 = 16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 = 74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62 = 40.3%), and trimethoprim/sulfamethoxazole (100/252 = 39.7), and multidrug resistance to ≥ 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and ~ 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern.
(© 2022. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
Databáze: MEDLINE
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