Cutaneous infection by non-diphtheria-toxin producing and penicillin-resistant Corynebacterium diphtheriae strain in a patient with diabetes mellitus.

Autor:	Batista Araújo MR; Operational Technical Nucleus, Microbiology, Hermes Pardini Institute. Av. das Nações, 3801 - Parque Jardim Itaú, Minas Gerais, Brazil., Bernardes Sousa MÂ; Operational Technical Nucleus, Microbiology, Hermes Pardini Institute. Av. das Nações, 3801 - Parque Jardim Itaú, Minas Gerais, Brazil., Seabra LF; Operational Technical Nucleus, Microbiology, Hermes Pardini Institute. Av. das Nações, 3801 - Parque Jardim Itaú, Minas Gerais, Brazil., Caldeira LA; Operational Technical Nucleus, Microbiology, Hermes Pardini Institute. Av. das Nações, 3801 - Parque Jardim Itaú, Minas Gerais, Brazil., Faria CD; Bacterial and Fungal Diseases Service, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil., Bokermann S; Center of Bacteriology, Adolfo Lutz Institute, Secretary of Health of the State of São Paulo, Brazil., Sant'Anna LO; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculty of Medical Sciences, Rio de Janeiro State University, The Collaborating Center for Reference and Research on Diphtheria, National Health Foundation, Ministry of Health, Rio de Janeiro, Brazil., Dos Santos LS; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculty of Medical Sciences, Rio de Janeiro State University, The Collaborating Center for Reference and Research on Diphtheria, National Health Foundation, Ministry of Health, Rio de Janeiro, Brazil., Mattos-Guaraldi AL; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculty of Medical Sciences, Rio de Janeiro State University, The Collaborating Center for Reference and Research on Diphtheria, National Health Foundation, Ministry of Health, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	Access microbiology [Access Microbiol] 2021 Nov 30; Vol. 3 (11), pp. 000284. Date of Electronic Publication: 2021 Nov 30 (Print Publication: 2021).
DOI:	10.1099/acmi.0.000284
Abstrakt:	Diphtheria is a potentially fatal infection, mostly caused by diphtheria toxin (DT)-producing Corynebacterium diphtheriae strains. During the last decades, the isolation of DT-producing C. diphtheriae strains has been decreasing worldwide. However, non-DT-producing C. diphtheriae strains emerged as causative agents of cutaneous and invasive infections. Although endemic in countries with warm climates, cutaneous diphtheria is rarely reported in Brazil. Presently, an unusual case of skin lesion in a Brazilian elderly diabetic patient infected by a penicillin-resistant non-DT-producing C. diphtheriae strain was reported. Laboratory diagnosis included mass spectrometry and multiplex PCR analyses. Since cutaneous diphtheria lesions are possible sources of secondary diphtheria cases and systemic diseases and considering that penicillin is the first line of antimicrobial agent for the treatment of these infections, the detection of penicillin-resistant strains of diphtheria bacilli should be a matter of concern. Thus, cases similar to the presently reported should be appropriately investigated and treated, particularly in patients with risk factor (s) for the development of C. diphtheriae invasive infections, such as diabetes. Moreover, health professionals must be aware of the presence of C. diphtheriae in cutaneous lesions of lower limbs, a common type of morbidity in diabetic patients, especially in tropical and subtropical countries. Competing Interests: The authors declare that there are no conflicts of interest. (© 2021 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu